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Prikvačeni tweet
Microexons in eIF4G control translation outputs in neurons and impact behaviour & memory. Check our new study
@MolecularCell https://doi.org/10.1016/j.molcel.2020.01.006 … With Blencowe, Cordes, Collingridge, Gingras,@Irimia, Forman-Kay, Sonenberg, Weatheritt,@MaWoodin labs@DonnellyCentre@UofTpic.twitter.com/7rPHJLExt7Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
Congratulations on a fantastic paper with surprising findings! Very grateful to have played a tiny part in this study.https://twitter.com/AbdelWahablab/status/1222920079114981378 …
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
Great collaborative effort across
@UofT! For a lay person's summary of the research, see our story: http://bit.ly/MicroexonAutism https://twitter.com/TPournatzis/status/1222592700702175234 …
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
Our last paper on prion-like protein phase separation and amyloid aggregation in Cell Reports. hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregationhttps://www.cell.com/cell-reports/fulltext/S2211-1247(19)31745-0#.XjB5MVi-WfQ.twitter …
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
Single-cell RNA-seq led to a surprising model of alternative splicing: individual cells make one isoform or the other, but rarely both in one cell. Carlos Buen Abad Najar, working with Nir Yosef and me, shows that this is an artifact of low mRNA recovery.https://www.biorxiv.org/content/10.1101/2019.12.19.883256v1 …
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
Online Now: Splicing Kinetics and Coordination Revealed by Direct Nascent RNA Sequencing through Nanoporeshttp://dlvr.it/RL8cPq
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
I am excited to share our latest work, in which we tackle the question: How can we predict which enhancers regulate which genes in which cell types? https://www.nature.com/articles/s41588-019-0538-0 … Thread
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
What is the role of nuclear stress bodies formed on
#lncRNA?@HiroseTetsuro reveal#HSATIII RNA assemblies are platforms facilitating SRSF#splicing factor phosphorylation to promote#intron retention following heat stress exposure http://embopress.org/doi/10.15252/embj.2019102729 …pic.twitter.com/viKDWLDtsU
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
A tour-de-force of continuous, while-organism laboratory evolution coupled with clever metabolic engineering.https://www.cell.com/cell/fulltext/S0092-8674(19)31230-9#.Xd8kNmfL-kE.twitter …
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
Check out our new work
@CellCellPress on how exon splicing activates cryptic promoters and controls gene expressionhttps://www.cell.com/cell/fulltext/S0092-8674(19)31223-1 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Thomas Gonatopoulos-Pournatzis proslijedio/la je TweetHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
A saturating mutagenesis CRISPR-Cas9 mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in embryonic stem cellshttp://dlvr.it/RJtFyB
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
From Lingling Chen lab - Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 Systemshttps://www.cell.com/molecular-cell/fulltext/S1097-2765(19)30802-0#.XdQz13LszyE.twitter …
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
New
@biorxivpreprint from the group, setting our sites on Cas12a (the#CRISPR enzyme formerly known as Cpf1) as a simpler system for multiplexed genetic screens. Thread... Optimization of AsCas12a for combinatorial genetic screens in human cellshttps://www.biorxiv.org/content/10.1101/747170v1 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
A database of transcript isoforms present in defined neuronal cell types (SpliceCode) reveals hundreds of alternative splicing events https://go.nature.com/2ZfKdVa pic.twitter.com/nRTMrYTlGw
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
Wow, this is cool! CRISPR cuts turn gels into biological watchdogs https://www.nature.com/articles/d41586-019-02542-3 …
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylationhttps://science.sciencemag.org/content/365/6455/825 …
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
Steven's paper is out on BioRxiv! Really cool manuscript that has it all - sequence-dependent molecular interaction strengths and phase diagrams, partition coefficients, "bursty" nucleation physics, and transcriptional amplification!https://www.biorxiv.org/content/10.1101/737387v1 …
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Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
Cool concept! Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates. https://www.ncbi.nlm.nih.gov/pubmed/31383972?dopt=Abstract …
#m6a#feedlyHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Thomas Gonatopoulos-Pournatzis proslijedio/la je Tweet
new preprint with
@dekegelb on the contribution of duplicate genes (paralogs) to the variable essentiality of genes in cancer cell lines: https://www.biorxiv.org/content/10.1101/716043v1 …. Thread: We know from studies in model organisms (mostly budding yeast) that paralogs are less likely to be essentialPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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