Thomas Gonatopoulos-Pournatzis

@TPournatzis

CIHR PDF RNA biologist; CRISPR enthusiast; Studying gene regulation using functional genomics

Vrijeme pridruživanja: lipanj 2018.

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  1. Prikvačeni tweet

    Microexons in eIF4G control translation outputs in neurons and impact behaviour & memory. Check our new study With Blencowe, Cordes, Collingridge, Gingras, , Forman-Kay, Sonenberg, Weatheritt, labs

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  2. proslijedio/la je Tweet
    30. sij

    Congratulations on a fantastic paper with surprising findings! Very grateful to have played a tiny part in this study.

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  3. proslijedio/la je Tweet
    30. sij

    Great collaborative effort across ! For a lay person's summary of the research, see our story:

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  4. proslijedio/la je Tweet
    28. sij

    Our last paper on prion-like protein phase separation and amyloid aggregation in Cell Reports. hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation

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  5. proslijedio/la je Tweet
    20. pro 2019.

    Single-cell RNA-seq led to a surprising model of alternative splicing: individual cells make one isoform or the other, but rarely both in one cell. Carlos Buen Abad Najar, working with Nir Yosef and me, shows that this is an artifact of low mRNA recovery.

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  6. proslijedio/la je Tweet
    12. pro 2019.

    Online Now: Splicing Kinetics and Coordination Revealed by Direct Nascent RNA Sequencing through Nanopores

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  7. proslijedio/la je Tweet
    2. pro 2019.

    I am excited to share our latest work, in which we tackle the question: How can we predict which enhancers regulate which genes in which cell types? Thread 👇 1/

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  8. proslijedio/la je Tweet
    29. stu 2019.

    What is the role of nuclear stress bodies formed on ? reveal RNA assemblies are platforms facilitating SRSF factor phosphorylation to promote retention following heat stress exposure

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  9. proslijedio/la je Tweet
    28. stu 2019.

    A tour-de-force of continuous, while-organism laboratory evolution coupled with clever metabolic engineering.

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  10. proslijedio/la je Tweet
    28. stu 2019.

    Check out our new work on how exon splicing activates cryptic promoters and controls gene expression

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  11. proslijedio/la je Tweet
    27. stu 2019.
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  12. proslijedio/la je Tweet
    22. stu 2019.

    A saturating mutagenesis CRISPR-Cas9 mediated functional genomic screen identifies cis- and trans-regulatory elements of Oct4 in embryonic stem cells

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  13. proslijedio/la je Tweet
    19. stu 2019.

    From Lingling Chen lab - Dynamic Imaging of RNA in Living Cells by CRISPR-Cas13 Systems

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  14. proslijedio/la je Tweet
    28. kol 2019.

    New from the group, setting our sites on Cas12a (the enzyme formerly known as Cpf1) as a simpler system for multiplexed genetic screens. Thread... Optimization of AsCas12a for combinatorial genetic screens in human cells

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    A database of transcript isoforms present in defined neuronal cell types (SpliceCode) reveals hundreds of alternative splicing events

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  16. proslijedio/la je Tweet
    23. kol 2019.

    Wow, this is cool! CRISPR cuts turn gels into biological watchdogs

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  17. proslijedio/la je Tweet
    22. kol 2019.

    Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation

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  18. proslijedio/la je Tweet
    16. kol 2019.

    Steven's paper is out on BioRxiv! Really cool manuscript that has it all - sequence-dependent molecular interaction strengths and phase diagrams, partition coefficients, "bursty" nucleation physics, and transcriptional amplification!

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  19. proslijedio/la je Tweet
    7. kol 2019.

    Cool concept! Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates.

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  20. proslijedio/la je Tweet
    29. srp 2019.

    new preprint with on the contribution of duplicate genes (paralogs) to the variable essentiality of genes in cancer cell lines: . Thread: We know from studies in model organisms (mostly budding yeast) that paralogs are less likely to be essential

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