Skip to content
By using Twitter’s services you agree to our Cookies Use. We and our partners operate globally and use cookies, including for analytics, personalisation, and ads.

For the best Twitter experience, please use Microsoft Edge, or install the Twitter app from Microsoft Store.

  • Home Home Home, current page.
  • About

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @
  • Language: English
    • Bahasa Indonesia
    • Bahasa Melayu
    • Català
    • Čeština
    • Dansk
    • Deutsch
    • English UK
    • Español
    • Filipino
    • Français
    • Hrvatski
    • Italiano
    • Magyar
    • Nederlands
    • Norsk
    • Polski
    • Português
    • Română
    • Slovenčina
    • Suomi
    • Svenska
    • Tiếng Việt
    • Türkçe
    • Ελληνικά
    • Български език
    • Русский
    • Српски
    • Українська мова
    • עִבְרִית
    • العربية
    • فارسی
    • मराठी
    • हिन्दी
    • বাংলা
    • ગુજરાતી
    • தமிழ்
    • ಕನ್ನಡ
    • ภาษาไทย
    • 한국어
    • 日本語
    • 简体中文
    • 繁體中文
  • Have an account? Log in
    Have an account?
    · Forgot password?

    New to Twitter?
    Sign up
SusanneTilk's profile
Susanne Tilk
Susanne Tilk
Susanne Tilk
@SusanneTilk

Tweets

Susanne Tilk

@SusanneTilk

Biology PhD candidate @Stanford studying somatic evolution in cancer.

Stanford, CA
Joined January 2018

Tweets

  • © 2020 Twitter
  • About
  • Help Center
  • Terms
  • Privacy policy
  • Imprint
  • Cookies
  • Ads info
Dismiss
Previous
Next

Go to a person's profile

Saved searches

  • Remove
  • In this conversation
    Verified accountProtected Tweets @
Suggested users
  • Verified accountProtected Tweets @
  • Verified accountProtected Tweets @

Promote this Tweet

Block

  • Tweet with a location

    You can add location information to your Tweets, such as your city or precise location, from the web and via third-party applications. You always have the option to delete your Tweet location history. Learn more

    Your lists

    Create a new list


    Under 100 characters, optional

    Privacy

    Copy link to Tweet

    Embed this Tweet

    Embed this Video

    Add this Tweet to your website by copying the code below. Learn more

    Add this video to your website by copying the code below. Learn more

    Hmm, there was a problem reaching the server.

    By embedding Twitter content in your website or app, you are agreeing to the Twitter Developer Agreement and Developer Policy.

    Preview

    Why you're seeing this ad

    Log in to Twitter

    · Forgot password?
    Don't have an account? Sign up »

    Sign up for Twitter

    Not on Twitter? Sign up, tune into the things you care about, and get updates as they happen.

    Sign up
    Have an account? Log in »

    Two-way (sending and receiving) short codes:

    Country Code For customers of
    United States 40404 (any)
    Canada 21212 (any)
    United Kingdom 86444 Vodafone, Orange, 3, O2
    Brazil 40404 Nextel, TIM
    Haiti 40404 Digicel, Voila
    Ireland 51210 Vodafone, O2
    India 53000 Bharti Airtel, Videocon, Reliance
    Indonesia 89887 AXIS, 3, Telkomsel, Indosat, XL Axiata
    Italy 4880804 Wind
    3424486444 Vodafone
    » See SMS short codes for other countries

    Confirmation

     

    Welcome home!

    This timeline is where you’ll spend most of your time, getting instant updates about what matters to you.

    Tweets not working for you?

    Hover over the profile pic and click the Following button to unfollow any account.

    Say a lot with a little

    When you see a Tweet you love, tap the heart — it lets the person who wrote it know you shared the love.

    Spread the word

    The fastest way to share someone else’s Tweet with your followers is with a Retweet. Tap the icon to send it instantly.

    Join the conversation

    Add your thoughts about any Tweet with a Reply. Find a topic you’re passionate about, and jump right in.

    Learn the latest

    Get instant insight into what people are talking about now.

    Get more of what you love

    Follow more accounts to get instant updates about topics you care about.

    Find what's happening

    See the latest conversations about any topic instantly.

    Never miss a Moment

    Catch up instantly on the best stories happening as they unfold.

    Susanne Tilk‏ @SusanneTilk 16 Sep 2019
    • Report Tweet

    Really excited to share the first chapter of my PhD on how genome-wide linkage in cancer reduces the efficacy of selection via Hill-Robertson interference (HRI), with mentors @cd_mcfarland, @PetrovADmitri and @cncurtis. https://bit.ly/2lTDQnT  (1/10)

    1:22 PM - 16 Sep 2019
    • 58 Retweets
    • 154 Likes
    • Chambi Chachage (CC) Abaho Ivan Daniel Shaykevich Sage Gibbons Daniel Kim Ben Weisburd 🇵 🇩 🅱🅾🅽🅶🅺🅸🆈🆄🅽🅶 Alex Cagan Nicole Moyen
    5 replies 58 retweets 154 likes
      1. New conversation
      2. Susanne Tilk‏ @SusanneTilk 16 Sep 2019
        • Report Tweet

        Here, we try to resolve why signals of negative selection are largely absent in cancer, yet pre-dominant in the human germ-line. (2/10)

        1 reply 0 retweets 5 likes
        Show this thread
      3. Susanne Tilk‏ @SusanneTilk 16 Sep 2019
        • Report Tweet

        We hypothesized that since tumors evolve asexually, under the constraints of genome-wide linkage, mutations are unable to be removed by negative selection (or favored by positive selection). (3/10)

        1 reply 0 retweets 6 likes
        Show this thread
      4. Susanne Tilk‏ @SusanneTilk 16 Sep 2019
        • Report Tweet

        Since linkage effects get stronger as mutation rates increase, tumors with elevated mutational burdens should be particularly inefficient at removing deleterious passengers due to genetic hitchhiking and Muller’s Ratchet. (4/10)pic.twitter.com/vVW4z6C6q1

        1 reply 0 retweets 6 likes
        Show this thread
      5. Susanne Tilk‏ @SusanneTilk 16 Sep 2019
        • Report Tweet

        To test this idea, we calculated dN/dS in tumors stratified by their mutational burden and observe that negative and positive selection attenuates as more mutations accumulate in tumors. (5/10)pic.twitter.com/WF1WIJ02mV

        1 reply 0 retweets 3 likes
        Show this thread
      6. Susanne Tilk‏ @SusanneTilk 16 Sep 2019
        • Report Tweet

        We see the same trend in somatic CNAs. Using a dN/dS-style statistic called dE/dI (fractional overlap of CNAs in [E]xonic versus [I]ntergenic/[I]ntronic regions) – we similarly see that selection on CNAs attenuates as the mutational burden increases. (6/10)pic.twitter.com/LUg6hlRJFk

        1 reply 0 retweets 2 likes
        Show this thread
      7. Susanne Tilk‏ @SusanneTilk 16 Sep 2019
        • Report Tweet

        Importantly, we see that attenuated selection on CNAs and SNVs is generic to tumor evolution. This pattern persists across broad and specific tumor sub-type categories. (7/10)pic.twitter.com/bKJ8vSbQUV

        1 reply 0 retweets 2 likes
        Show this thread
      8. Susanne Tilk‏ @SusanneTilk 16 Sep 2019
        • Report Tweet

        Finally, we demonstrate that a simple evolutionary model incorporating HRI can explain these observed patterns of selection and allowed us to estimate the mean fitness effects of passengers (~1%) and drivers (~18%) – much larger than previously estimated. (8/10)

        1 reply 0 retweets 6 likes
        Show this thread
      9. Susanne Tilk‏ @SusanneTilk 16 Sep 2019
        • Report Tweet

        Thus, this allowed us to estimate that in elevated mutational burden tumors (>95% of cancers), deleterious passengers accumulate and confer an individually-weak, but collectively-substantial fitness cost of ~40% that impacts tumor progression. (9/10)

        1 reply 0 retweets 8 likes
        Show this thread
      10. Susanne Tilk‏ @SusanneTilk 16 Sep 2019
        • Report Tweet

        How successful tumors overcome this deleterious load is an exciting, open question. Similar to constraints in germ-line evolution, we think that preventing protein mis-folding is an important first step. We’d love to hear what you think! (10/10)

        1 reply 2 retweets 8 likes
        Show this thread
      11. End of conversation
      1. Chris D McFarland‏ @cd_mcfarland 16 Sep 2019
        • Report Tweet
        Replying to @SusanneTilk @PetrovADmitri @cncurtis

        I also want to thank my graduate advisor @leonidmirny, who first got me interested in deleterious passengers and their role in cancer.

        0 replies 0 retweets 3 likes
        Thanks. Twitter will use this to make your timeline better. Undo
        Undo

    Loading seems to be taking a while.

    Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.

      Promoted Tweet

      false

      • © 2020 Twitter
      • About
      • Help Center
      • Terms
      • Privacy policy
      • Imprint
      • Cookies
      • Ads info