Susanne Tilk

@SusanneTilk

Biology PhD candidate studying somatic evolution in cancer.

Vrijeme pridruživanja: siječanj 2018.

Medijski sadržaj

  1. 16. ruj 2019.

    Importantly, we see that attenuated selection on CNAs and SNVs is generic to tumor evolution. This pattern persists across broad and specific tumor sub-type categories. (7/10)

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  2. 16. ruj 2019.

    We see the same trend in somatic CNAs. Using a dN/dS-style statistic called dE/dI (fractional overlap of CNAs in [E]xonic versus [I]ntergenic/[I]ntronic regions) – we similarly see that selection on CNAs attenuates as the mutational burden increases. (6/10)

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  3. 16. ruj 2019.

    To test this idea, we calculated dN/dS in tumors stratified by their mutational burden and observe that negative and positive selection attenuates as more mutations accumulate in tumors. (5/10)

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  4. 16. ruj 2019.

    Since linkage effects get stronger as mutation rates increase, tumors with elevated mutational burdens should be particularly inefficient at removing deleterious passengers due to genetic hitchhiking and Muller’s Ratchet. (4/10)

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  5. 7. lip 2018.
    Odgovor korisniku/ci

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