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SteveJoffe's profile
Steve Joffe
Steve Joffe
Steve Joffe
@SteveJoffe

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Steve Joffe

@SteveJoffe

Research ethics, pediatric ethics, cancer ethics, genomethics, science policy @ UPenn. Grateful immigrant. Speak only for myself. R/Ts≠likes. He/him.

Philadelphia, PA
medicalethics.med.upenn.edu/people/faculty…
Joined June 2011

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    Steve Joffe‏ @SteveJoffe 18 Dec 2020

    1/ The hints that single doses of the Pfizer/BioNTech & Moderna vaccine are protective are really important, & I'm glad @zeynep & @michaelmina_lab call for studying them. The case for comparing 2 doses to 1 dose plus placebo is compelling. https://www.nytimes.com/2020/12/18/opinion/coronavirus-vaccine-doses.html …pic.twitter.com/k41BA7Npeg

    5:19 AM - 18 Dec 2020
    • 8 Retweets
    • 41 Likes
    • I Kate Saylor, Ph.D. Joe Kent Jeffrey P Jones Marcus Carr Dustin Krutsinger MD MSCE Mark Alonge Bassaces M
    4 replies 8 retweets 41 likes
      1. New conversation
      2. Steve Joffe‏ @SteveJoffe 18 Dec 2020

        2/ Ideal would have been for Pfizer & Moderna to invite participants in the placebo group to be randomized between 1 vs. 2 doses, but unfortunately that is not going to happen.

        1 reply 1 retweet 7 likes
        Show this thread
      3. Steve Joffe‏ @SteveJoffe 18 Dec 2020

        3/ Next best is to do trials among people who aren't going to be eligible for vaccination under the EUA for a while. The incentive to join the trial and get vaccinated now would be strong.

        1 reply 1 retweet 5 likes
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      4. Steve Joffe‏ @SteveJoffe 18 Dec 2020

        4/ Even better would be for Moderna & Pfizer to run a joint trial that allowed direct comparisons between 1 and 2 doses of both vaccines. That could be the start of the platform trial we urgently need.https://jamanetwork.com/journals/jama/fullarticle/2774383 …

        1 reply 1 retweet 5 likes
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      5. Steve Joffe‏ @SteveJoffe 18 Dec 2020

        Steve Joffe Retweeted

        5/ @CohenProf sees potential research ethics challenges. I'm not concerned. There's a pressing scientific question and, even if 1 dose (or a delayed booster) is less protective than 2, informed adults can accept this risk for themselves. https://twitter.com/CohenProf/status/1339912099166887936?s=20 …

        Steve Joffe added,

        This Tweet is unavailable.
        2 replies 2 retweets 8 likes
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      6. Steve Joffe‏ @SteveJoffe 18 Dec 2020

        6/ Further, we gain protection 2 ways: by protecting ourselves, and by reducing spread in the population*. If vaccinating twice as many does more of the latter, we all benefit from that.

        2 replies 1 retweet 9 likes
        Show this thread
      7. Steve Joffe‏ @SteveJoffe 18 Dec 2020

        7/ *The caveat, of course, is that we don't yet know for sure that the vaccines reduce asymptomatic infection and ability to transmit disease. These data are coming, and urgently needed, but are not in hand yet.

        2 replies 1 retweet 5 likes
        Show this thread
      8. End of conversation
      1. Ira Goldman  🦆 🦆 🦆‏ @KDbyProxy 20 Dec 2020
        Replying to @SteveJoffe @zeynep @michaelmina_lab

        But aren't some in the high-risk groups in such groups because they are older and have less robust immune systems? Would good test results of a single dose in a low-risk group be meaningful as to that high-risk population?

        0 replies 0 retweets 0 likes
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      2. Cure CFS (and long-COVID) / armchair non-expert‏ @CureCFS 24 Dec 2020
        Replying to @SteveJoffe @zeynep @michaelmina_lab

        So... why are these low-risk populations first in line for the vaccinations?? 😥

        1 reply 0 retweets 0 likes
      3. Eric Stein‏ @toba 3 Jan 2021
        Replying to @CureCFS @SteveJoffe and

        I think this means low risk of severe disease if infected, not low exposure risk.

        0 replies 0 retweets 0 likes
      4. End of conversation

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