Nick Steinmetz

@SteinmetzNeuro

Neuroscientist. Assistant Professor at the University of Washington in Seattle.

Vrijeme pridruživanja: kolovoz 2017.

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  1. Prikvačeni tweet
    27. stu 2019.

    Our work on 'Distributed coding of choice, action, and engagement across the mouse brain' is published today in Nature! With , , and . Here's a quick recap and what's new since bioRxiv.

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  2. 22. sij

    Applications for our 2020 Neuropixels course in London are due this Friday - see below! Please pass on the info to anyone you think might be interested in learning to use Neuropixels.

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  3. proslijedio/la je Tweet

    After >2 years of effort by our team in 7 labs, we present to you: 3 million choices from 101 mice in a standardized decision-making task. 🐭 "A standardized and reproducible method to measure decision-making in mice" Story time! 🧵👇 1/10

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  4. proslijedio/la je Tweet
    3. sij

    Highly recommend for labs setting up . The UCL training course gave the a big jump start in getting our neuropixels rig going.

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  5. 3. sij

    As in previous years, the course is free to admitted applicants thanks to generous funding from and hosting from ! Feel free to post here, or to email co-organizer and me, if you have any questions.

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  6. 3. sij

    Applications for the 2020 UCL Neuropixels training course are now open! It will be April 27-29 in London. Visit here () to apply, due Jan 24. Visit the course website to learn more about what will be covered:

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  7. proslijedio/la je Tweet
    25. pro 2019.

    1/n Motor cortex controls the arm by sending neural activity patterns to the spinal cord and brainstem. But how are these patterns generated? We study this question in our new paper in , with J-Z Guo, J Cohen, M Mischiati, , et al.

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  8. 27. stu 2019.

    Last but not least, many thanks to the consortium, especially Tim Harris, and its funders: , , , Gatsby. Thanks to and for postdoc funding, and thanks for being a great place to do this work!

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  9. 27. stu 2019.

    The data area all fully shared publicly now (), and see links therein for code too. Thanks to and the efforts of talented Steinmetz lab member , you can also access them in NWB format () if you prefer.

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  10. 27. stu 2019.

    These results delineate the coding of choice, action, and engagement across multiple brain systems, showing that none of these are as localized as we might wish they were! We have a lot more to learn in the future about the mechanisms coordinating these distributed computations!

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  11. 27. stu 2019.

    We saw that task engagement (trial-to-trial and comparing task with 'passive replay') correlates with a global pattern of changes: suppressed activity in cortex and enhanced activity subcortically. This could not be explained by measures of arousal, reward, or overt movements.

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  12. 27. stu 2019.

    Using a new extension of the classic 'jPSTH' analysis, using canonical correlations to look at timing differences between population activity across simultaneously recorded regions locked to task events, we see indistinguishable timing across these different choice regions.

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  13. 27. stu 2019.

    Coding of the specific action chosen, however, was much rarer, yet still distributed across key regions: frontal cortex, basal ganglia, and midbrain. Choice was encoded in unexpected areas incl Midbrain Reticular and Zona Incerta. Coding was distinct in midbrain versus forebrain.

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  14. 27. stu 2019.

    We observed non-specific coding of action initiation in individual neurons from nearly every region we recorded. Action encoding is global.

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  15. 27. stu 2019.

    In this study we used Neuropixels to record from ~30000 neurons in more than 40 regions of the mouse brain, both cortical and sub-cortical. During the recordings, mice performed a visual discrimination task.

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  16. proslijedio/la je Tweet
    5. stu 2019.

    Calling all extracellular electrophysiologists! We want to hear about your software-related likes and dislikes, no matter what acquisition system you use. One randomly selected participant will win a $100 Newegg gift card…please visit to help us out!

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  17. proslijedio/la je Tweet

    Now out: read all about how efficiently shares data across labs, collects metadata, and built user interfaces for robust and efficient pipelines. Come and reuse our tools! With

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  18. proslijedio/la je Tweet

    Interested in joining us? The Hausser (UCL, London) and (UW, Seattle) labs are hiring IBL postdocs! Chat with and many others to find out what working in the team is like.

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  19. proslijedio/la je Tweet
    14. lis 2019.

    We’re releasing new large datasets to accelerate including our first – and the world’s largest – dataset of brain activity gathered using , a high-resolution probe that can record activity from hundreds of neurons simultaneously.

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  20. proslijedio/la je Tweet

    I'm recruiting postdocs! We use neural interfaces to study sensorimotor learning & make interfaces that use learning to restore function. Large-scale network recording/stim + computation + behavior in🐒. Interested? Find me at or see details here:

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