I wouldn't say that clinical trials are broken in general; I would say that some notions of clinical trials are broken.
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Even more problematic in
#psychotherapy research wh interventions developed in the lab suffer from ALL the prob of psych research in generalThanks. Twitter will use this to make your timeline better. UndoUndo
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As a trial stat, I agree we should better combine data and ideas. Can we invent an easier way to translate "cool ideas" into priors?
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here's an approach for updating priors during the course of a trial by S. Olesen,
@ThomasGurry and@ejalm http://journals.sagepub.com/doi/10.1177/0962280216688502 …
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Reproducibility crisis suggests broken as an accurate description.
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Maybe, but the solution you propose is far from effective. Translational attempts in pharmacology fail more than succeed 1/
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There is ample research on the difficulties & relevance of diagnosis, about the measures used 2 measure outcome etc 3/
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It's easy 2 say "oh let's study mental disorders causes in th lab, then translate 2 interventions & measure variables related 2 causes" 4/
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In reality, problems @ every step. Using analogue samples to study "causes" in th lab, translating 4 patients, defining mental conditions 5/
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Not 2 mention defining relevant outcomes, developing reliable & valid instruments part when not dealing w/ objective data like mortality 6/
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