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Prikvačeni tweet
My
#TEDxAarhus talk about "How vaccines train the immune system in ways no one expected" is online: https://www.youtube.com/watch?v=_d8PNlXHJ48 …#nsevac#research#vaccinations#vaccinesasimmunetrainers#tedxtalkHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Christine Stabell Benn proslijedio/la je Tweet
This is highly problematic: Electronic patient records systems used by thousands of doctors were programmed to automatically suggest opioids at treatment, thanks to a secret deal between the software maker and a drug company https://www.bloomberg.com/news/articles/2020-01-29/health-records-company-pushed-opioids-to-doctors-in-secret-deal … via
@technologyHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Christine Stabell Benn proslijedio/la je Tweet
Can safety questions about the
#malariavaccine be answered after only 24 months?: http://bit.ly/2OoRSci Great analysis by@StabellBenn for@bmj_latest on safety concerns and challenges.pic.twitter.com/aaoJeaxq3d
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Christine Stabell Benn proslijedio/la je Tweet
In the past 40 years, Danish research has shown that the story of vaccines is not quite as simple as
@WHO , national health authorities and others portray it.https://www.sciencenews.dk/en/vaccines-an-unresolved-story-in-many-ways …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Christine Stabell Benn proslijedio/la je TweetHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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Christine Stabell Benn proslijedio/la je Tweet
That's a very good point. To me, one of the issue is that this is how pharmaceuticals are discussed--each has efficacy, side effects, pricing, etc.... Vaccines don't get this type of media treatment. They are just seen as an immediate good.
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Christine Stabell Benn proslijedio/la je Tweet
That's another way of looking at it, yes. Or it could be that both are happening simultaneously, with variance in different populations. Point is that we continue with this half a sandwich conversation. It's all peanut butter and no jelly. More honest talk about safety.
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A story of potential interest for those concerned that interventions are developed based on intermediate outcomes. In this case, malaria protection may come at the price of higher overall mortality for girls.
@AndersPerner@adamcifu@VPrasadMDMPH@KarstenJuhl@PGtzsche1@dnunan79https://twitter.com/StabellBenn/status/1223329623536295937 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
I could not agree more!https://twitter.com/thackerpd/status/1223594259976245248 …
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Christine Stabell Benn proslijedio/la je Tweet
Concise and clear summary of the story about the new malaria vaccine.
@WHO and@WHOAFRO there are serious concerns being raised. Please confirm that you will address these. Trials should be done carefully and with consent of partipants.#vaccineshttps://twitter.com/StabellBenn/status/1223329623536295937 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Christine Stabell Benn proslijedio/la je Tweet
What the world needs: Malaria vaccine What the world does not need: Sexist medical systems that ignore girl child mortality rates.
@WHO what's going on here?https://twitter.com/StabellBenn/status/1223329623536295937 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
It is a real risk is that the pilot study will find no increased female mortality due to these shortcomings, and therefore the vaccine will be approved for use in Africa even though it has harmful non-specific effects for girls. What will
@WHO do to repair this situation?Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
The lack of participant registration, the potentially flawed death registration, the short follow-up and the low coverage all act in the same direction: making it difficult to document increased mortality among vaccinated girls, even if it should exist.
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Adding to the problems, the first reports from the pilot study indicate that vaccine coverage is very low. So far in Malawi, the first dose reached about half of the children targeted, further diminishing the power to detect any mortality difference. https://nypost.com/2020/01/17/first-ever-malaria-vaccine-tried-out-in-babies-in-3-african-nations/ …?
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This means that most study children will only have had 1-3 of the 4 vaccines before a decision is made. As we point out, the negative vaccine effects became worse with additional doses, e.g. girls had more than 3-fold higher mortality after more vaccines.https://www.bmj.com/content/bmj/368/bmj.l6920.full.pdf …
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The latest development is worrying: The pilot study was to have 720,000 children and last 4 years to capture a negative effect of the vaccine on girls’ mortality. But now, after pressure from
@GSK, WHO decided to make a decision already after 2 years. https://www.who.int/immunization/sage/meetings/2019/april/1_Session_7_Framework_for_Policy_Decision_on_RTSS-AS01_-_MALARIA_VACCINE_(for_print).pdf …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Deaths are difficult to keep track of. E.g. in Malawi there are no official death registries, hospital staff have not routinely registered hospital deaths, and to report deaths outside hospital the study relies on town chiefs, many being illiterate.https://www.sciencemag.org/news/2019/11/first-malaria-vaccine-rolled-out-africa-despite-limited-efficacy-and-nagging-safety …
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Is this then being done? Is it ensured that every participant and each death in this pilot study is registered? Unfortunately no. The vaccine is added to the vaccination program in some regions, but not in others. There is no individual registration of participants.
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The only justification for a large pilot implementation study would be if the increased mortality in girls was a chance finding. The probability is <0.001. But it could be. But given this situation, it is indispensable to follow children very closely for mortality.
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However, all available evidence suggests that if you are a girl, the vaccine may reduce your risk of malaria, but this benefit is offset by a negative non-specific effect
#NSEvac (also seen for other non-live vaccines) that leads to increased OVERALL mortality.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
The pilot study was launched in Malawi in April 2019, Ghana and Kenya followed.
@DrTedros stated that "The malaria vaccine has the potential to save tens of thousands of children’s lives”. Excited media praised the possibility to combat malaria.https://www.who.int/news-room/detail/23-04-2019-malaria-vaccine-pilot-launched-in-malawi …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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