No no no no no GOD no. A computer model, at best, gives you a lead to start trials. You don't label something an X agonist because the model says so!https://twitter.com/nickpwing/status/960952612551118848 …
Anti-authoritarian, bleeding-heart Stirnerite,
. Banned in Sweden. SubGenius, Zhuangist, white-hat troll. Defrocked mathematician. Brain problems.
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St. Rev ☯️ 🏴 😻 Retweeted Nick Wing
No no no no no GOD no. A computer model, at best, gives you a lead to start trials. You don't label something an X agonist because the model says so!https://twitter.com/nickpwing/status/960952612551118848 …
St. Rev ☯️ 🏴 😻 added,
It’s much worse than that. If a computer model said Y might be an X agonist, the first thing you do is see whether it even binds to the purified receptor in vitro. That is cheap & quick & easy.
does the FDA ever do competent things as well, sometimes? I only ever see negative takes on them.
I think the consensus among the lunatics I listen to is that they do more harm than good because their institutional incentives are misaligned -- they are punished for allowing bad medicines, but not for forbidding good ones, roughly.
Canonical comparison here is thalidomide vs. beta blockers. Excess morbidity and mortality from not approving beta blockers for X years was far greater than the excess morbidity and mortality from approving thalidomide. But heads rolled for the latter, bc visible vs. invisible.
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