No no no no no GOD no. A computer model, at best, gives you a lead to start trials. You don't label something an X agonist because the model says so!https://twitter.com/nickpwing/status/960952612551118848 …
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I think the consensus among the lunatics I listen to is that they do more harm than good because their institutional incentives are misaligned -- they are punished for allowing bad medicines, but not for forbidding good ones, roughly.
Canonical comparison here is thalidomide vs. beta blockers. Excess morbidity and mortality from not approving beta blockers for X years was far greater than the excess morbidity and mortality from approving thalidomide. But heads rolled for the latter, bc visible vs. invisible.
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