It’s much worse than that. If a computer model said Y might be an X agonist, the first thing you do is see whether it even binds to the purified receptor in vitro. That is cheap & quick & easy.
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does the FDA ever do competent things as well, sometimes? I only ever see negative takes on them.
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I think the consensus among the lunatics I listen to is that they do more harm than good because their institutional incentives are misaligned -- they are punished for allowing bad medicines, but not for forbidding good ones, roughly.
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Canonical comparison here is thalidomide vs. beta blockers. Excess morbidity and mortality from not approving beta blockers for X years was far greater than the excess morbidity and mortality from approving thalidomide. But heads rolled for the latter, bc visible vs. invisible.
End of conversation
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Maybe they should call it an opioidoid.
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Maybe FDA and DEA need to be dissolved.
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Agencyoid
End of conversation
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"hey, all we said was we're confident declaring this, we never said our confidence had any rational basis to it"
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. Banned in Sweden. SubGenius, Zhuangist, white-hat troll. Defrocked mathematician. Brain problems.