There's short-term tolerance to euphoric effects, which develops and fades quickly on a scale of hours, eg https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628209/figure/Fig5/ …
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Replying to @St_Rev @Sekenneri
But that's not the kind of tolerance involved in withdrawal, which AFAICT isn't really covered in this paper.
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Replying to @St_Rev
It is. The same mechanism that leads to tolerance leads to physical dependence; the drugged state becomes the baseline 1/
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Replying to @Sekenneri @St_Rev
Because it's the new baseline, more drug is needed to produce the same effects 2/
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Replying to @Sekenneri @St_Rev
Because it's the new baseline, removing the drug puts the body in a deranged state, until natural chemistry straightens out again
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Replying to @Sekenneri @St_Rev
This particular paper doesn't address physical dependence because physical dependence is thoroughly settled science
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Replying to @Sekenneri
...So you linked a paper that isn't relevant to the argument you're making.
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Replying to @St_Rev
My argument is that physical dependence/tolerance to opiods can and does develop on a timescale of days, under the claimed conditions
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Replying to @Sekenneri
Tolerance to euphoric effects is distinct from withdrawal syndrome! The timescales are completely different!
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Euphoric effects diminish within hours, endogenous endorphin production effects (responsible for discontinuation syndrome) take days-weeks.
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. Banned in Sweden. SubGenius, Zhuangist, white-hat troll. Defrocked mathematician. Brain problems.