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St_Rev's profile
St. Rev ☯️🏴😻
St. Rev ☯️🏴😻
St. Rev  ☯️ 🏴 😻
@St_Rev

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St. Rev  ☯️ 🏴 😻

@St_Rev

Anti-authoritarian, bleeding-heart Stirnerite, ☯️. Banned in Sweden. SubGenius, Zhuangist, white-hat troll. Defrocked mathematician. Brain problems.

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Joined May 2011

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    1. NIGHT INFORMATION‏ @Sekenneri 27 Oct 2017
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      Replying to @St_Rev

      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628209/ …

      1 reply 0 retweets 0 likes
    2. St. Rev  ☯️ 🏴 😻‏ @St_Rev 27 Oct 2017
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      Replying to @Sekenneri

      There's short-term tolerance to euphoric effects, which develops and fades quickly on a scale of hours, eg https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628209/figure/Fig5/ …

      1 reply 0 retweets 0 likes
    3. St. Rev  ☯️ 🏴 😻‏ @St_Rev 27 Oct 2017
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      Replying to @St_Rev @Sekenneri

      But that's not the kind of tolerance involved in withdrawal, which AFAICT isn't really covered in this paper.

      1 reply 0 retweets 0 likes
    4. NIGHT INFORMATION‏ @Sekenneri 27 Oct 2017
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      Replying to @St_Rev

      It is. The same mechanism that leads to tolerance leads to physical dependence; the drugged state becomes the baseline 1/

      1 reply 0 retweets 0 likes
    5. NIGHT INFORMATION‏ @Sekenneri 27 Oct 2017
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      Replying to @Sekenneri @St_Rev

      Because it's the new baseline, more drug is needed to produce the same effects 2/

      1 reply 0 retweets 0 likes
    6. NIGHT INFORMATION‏ @Sekenneri 27 Oct 2017
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      Replying to @Sekenneri @St_Rev

      Because it's the new baseline, removing the drug puts the body in a deranged state, until natural chemistry straightens out again

      1 reply 0 retweets 0 likes
    7. NIGHT INFORMATION‏ @Sekenneri 27 Oct 2017
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      Replying to @Sekenneri @St_Rev

      This particular paper doesn't address physical dependence because physical dependence is thoroughly settled science

      1 reply 0 retweets 0 likes
    8. St. Rev  ☯️ 🏴 😻‏ @St_Rev 27 Oct 2017
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      Replying to @Sekenneri

      ...So you linked a paper that isn't relevant to the argument you're making.

      1 reply 0 retweets 0 likes
    9. NIGHT INFORMATION‏ @Sekenneri 27 Oct 2017
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      Replying to @St_Rev

      My argument is that physical dependence/tolerance to opiods can and does develop on a timescale of days, under the claimed conditions

      1 reply 0 retweets 0 likes
    10. NIGHT INFORMATION‏ @Sekenneri 27 Oct 2017
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      Replying to @Sekenneri @St_Rev

      I think that paper supports that?

      1 reply 0 retweets 0 likes
      St. Rev  ☯️ 🏴 😻‏ @St_Rev 27 Oct 2017
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      Replying to @Sekenneri

      Tolerance to euphoric effects is distinct from withdrawal syndrome! The timescales are completely different!

      4:44 PM - 27 Oct 2017
      2 replies 0 retweets 0 likes
        1. St. Rev  ☯️ 🏴 😻‏ @St_Rev 27 Oct 2017
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          Replying to @St_Rev @Sekenneri

          Euphoric effects diminish within hours, endogenous endorphin production effects (responsible for discontinuation syndrome) take days-weeks.

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        2. NIGHT INFORMATION‏ @Sekenneri 27 Oct 2017
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          Replying to @St_Rev

          There's only one mechanism to the process. The difference in timescale is due to subjective effects in the individual user.

          1 reply 0 retweets 0 likes
        3. NIGHT INFORMATION‏ @Sekenneri 27 Oct 2017
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          Replying to @Sekenneri @St_Rev

          That the euphoria operates on a scale of hours does not support the argument that three days is too little time to develop a tolerance.

          1 reply 0 retweets 0 likes
        4. St. Rev  ☯️ 🏴 😻‏ @St_Rev 27 Oct 2017
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          Replying to @Sekenneri

          Tolerance and withdrawal syndrome are not the same thing. My assertion stands that three days is too little time to exhibit significant w/d.

          1 reply 0 retweets 0 likes
        5. St. Rev  ☯️ 🏴 😻‏ @St_Rev 27 Oct 2017
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          Replying to @St_Rev @Sekenneri

          Read the tweet thread. Guy had severe nausea, vomiting, cramps, diarrhea. Three days of percocet is not going to do this to you.

          1 reply 0 retweets 0 likes
        6. St. Rev  ☯️ 🏴 😻‏ @St_Rev 27 Oct 2017
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          Replying to @St_Rev @Sekenneri

          What will do that to you are a) postop infection b) RECENT KIDNEY SURGERY

          2 replies 0 retweets 0 likes
        7. St. Rev  ☯️ 🏴 😻‏ @St_Rev 27 Oct 2017
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          Replying to @St_Rev @Sekenneri

          (Also possible: delayed allergic reaction to the meds. That's almost the opposite of addiction, though.)

          1 reply 0 retweets 0 likes
        8. NIGHT INFORMATION‏ @Sekenneri 27 Oct 2017
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          Replying to @St_Rev

          The symptoms have no particular resemblance to any degree of allergic reaction, and it's very unlikely that the guy had never had Tylenol

          1 reply 0 retweets 0 likes
        9. NIGHT INFORMATION‏ @Sekenneri 27 Oct 2017
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          Replying to @Sekenneri @St_Rev

          I have no idea what else he might have had during the lead up to surgery, so I can't refute that, and it's not implausible.

          1 reply 0 retweets 0 likes
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