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He blamed the vicodin when he should have gone back to the doctor. That's where opioid FUD leads.
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There's short-term tolerance to euphoric effects, which develops and fades quickly on a scale of hours, eg https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628209/figure/Fig5/ …
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But that's not the kind of tolerance involved in withdrawal, which AFAICT isn't really covered in this paper.
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It is. The same mechanism that leads to tolerance leads to physical dependence; the drugged state becomes the baseline 1/
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Because it's the new baseline, more drug is needed to produce the same effects 2/
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Because it's the new baseline, removing the drug puts the body in a deranged state, until natural chemistry straightens out again
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This particular paper doesn't address physical dependence because physical dependence is thoroughly settled science
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...So you linked a paper that isn't relevant to the argument you're making.
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I'd bet on a delayed reaction directly to the opiate.
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Possible. Or just having had kidney surgery and trying to tough it out too early without pain meds.
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3.5 days is a very reasonable timescale for the development of hydrocodone tolerance, particularly if you chow down on the stuff
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. Banned in Sweden. SubGenius, Zhuangist, white-hat troll. Defrocked mathematician. Brain problems.