Selective Serotonin Rewait what http://j.mp/OKt7WU
-
-
@St_Rev Not really—the issue in this case is target selection (i.e. serotonin) rather than “rational” (i.e. receptor binding model). -
@Meaningness What I mean is, picking compounds to hit X, then 20 years later finding that hitting X has nothing to do with the mechanism...
End of conversation
New conversation -
-
-
@St_Rev To extent that SSRIs work only accidentally, yes it’s evidence that overall system is a cargo cult. On other hand, science is hard!Thanks. Twitter will use this to make your timeline better. UndoUndo
-
-
-
@St_Rev Pre-rational methods also often isolated a target, but lacking a binding model, ligand discovery/development was a random walk.Thanks. Twitter will use this to make your timeline better. UndoUndo
-
-
-
@St_Rev Rational design methods do have severe problems, but those aren’t obviously implicated here. Also, overall system is a disaster.Thanks. Twitter will use this to make your timeline better. UndoUndo
-
-
-
@St_Rev On still other hand, misaligned incentives and general incompetence make drug R&D much less effective than it could be.Thanks. Twitter will use this to make your timeline better. UndoUndo
-
Loading seems to be taking a while.
Twitter may be over capacity or experiencing a momentary hiccup. Try again or visit Twitter Status for more information.
. Banned in Sweden. SubGenius, Zhuangist, white-hat troll. Defrocked mathematician. Brain problems.