@St_Rev >I may have made it all up. Anyway, the “whack it and see if that helps” theory seems plausible to me.
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@Meaningness Failure of the serotonin hypothesis is some evidence for the "rational drug design is a trillion dollar cargo cult" hypothesis. -
@St_Rev Not really—the issue in this case is target selection (i.e. serotonin) rather than “rational” (i.e. receptor binding model). -
@Meaningness What I mean is, picking compounds to hit X, then 20 years later finding that hitting X has nothing to do with the mechanism...
End of conversation
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@St_Rev My recollection is that many/most researchers now think “SSRI”s don’t work by inhibiting serotonin reuptake. Time constant is wrong>Thanks. Twitter will use this to make your timeline better. UndoUndo
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@St_Rev >among other lines of evidence. Neurogenesis promotion is an alternate theory. However, Wikipedia SSRI article doesn’t say this, so>Thanks. Twitter will use this to make your timeline better. UndoUndo
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. Banned in Sweden. SubGenius, Zhuangist, white-hat troll. Defrocked mathematician. Brain problems.