Shorter Lab Members

@ShorterLabGroup

We are a group of scientists working to combat protein misfolding as a way to understand and treat neurodegenerative diseases. (student run)

Philadelphia, PA
Vrijeme pridruživanja: listopad 2012.

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  1. Prikvačeni tweet

    science typing hacks for mac: option + j = ∆ option + k = ˚ option + m = µ option + p = π option + x = ≈ option + z = Ω

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  2. proslijedio/la je Tweet
    prije 9 sati

    Exciting new study by the group of Jack Taunton in . Using a sulfonyl fluoride with a rigid and stereochemically defined linker for rapid and selective engagement of HSP90 on a lysine residue.

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    3. velj

    A new magnet slogan is born: "Deadlines lose meaning when you deal with evolutionary timescales"

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    It's always great to meet with our alumni , who is so creative and exceptional in research. The best part is we have many exciting overlaps in research. Proud of alumni from

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    Using image data, Lundberg et al. spatially map 1300+ nucleolar proteins, incl. 157 at the nucleoplasmic border, and confirm previous reports that nucleolar proteins are enriched with disordered regions |

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  6. A beautiful talk today by for the department about a method to distinguish between oligomers and aggregates in cells!! For more of his group’s work check out this paper from last year

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    4. velj

    i had an idea for a new optical genetic tool in 2013. seven years later, two people in my lab did some work, and today, we got our first images that suggest this tool might actually have worked. it might be the long game, but days like today are pretty fun.

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  8. proslijedio/la je Tweet
    prije 16 sati

    Widespread remodeling of proteome solubility in response to different protein homeostasis stresses | PNAS

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    prije 23 sata

    Getting to use dye instead of transfecting is sensory / data overload!

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  10. proslijedio/la je Tweet
    prije 18 sati

    Online Now: Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression

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    The ageing epigenome and its rejuvenation

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    3. velj

    APOE4 is known AD risk factor, while APOE2 is thought to be protective. Here, better defined (lack of) risk for APOE2 --> Exceptionally low likelihood of ’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

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    prije 21 sat

    a nice follow-up to earlier work from the Kundu group (): Application of a protein domain as chaperone for enhancing biological activity and stability of other proteins

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  15. Differences Between Human and Murine Tau at the N-terminal End

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  16. The Herpes Simplex Virus 1 Immediate Early Protein ICP22 Is a Functional Mimic of a Cellular J Chaperone Protein

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  17. Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro

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  18. DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations

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  19. proslijedio/la je Tweet
    prije 21 sat

    Nuclear bodies formed by polyQ-ataxin-1 protein are liquid RNA/protein droplets with tunable dynamics

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    4. velj
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  21. proslijedio/la je Tweet
    4. velj

    Enhanced stress tolerance through reduction of G3BP and suppression of stress granules

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