I design the systems for manufacturing, and also a member of the ISPE.
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Not counting the different manufacturer's of vaccines and the different method's of pharmaceutical processing. Validation for the FDA meets a narrow set of goals and guidelines for vaccines to be approved. The side affect's are almost impossible to determine for every individual.
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Luckily, we have a natural control group in the US, which for religious reasons, gets no vaccines. The Amish devout have been studied, and have nothing like the constilation of illnesses that the multivac people do.
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I avoid over-vaccing my DOGS for heavens sakes. I have titers done first to see if they are near or below therapeutic levels. We have a long way to go before we get good handle on immune system
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In the end though thats a statistical game. I have 4 kids and I dont really like vaccines, but risks are part of life, and utilitarianism a la Mill has to take its place here. My kids are fine and immunized. Thats not insignificant.
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