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Shai Carmi proslijedio/la je Tweet
An updated version of our (
@hakha_most@iagarwal2@daltonconley@jkpritch and@molly_przew) work on the factors affecting the performance of polygenic scores--beyond genetic ancestry—is accepted and now up@eLife https://elifesciences.org/articles/48376 [thread]pic.twitter.com/4PHQXiQJwm
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Interesting: ball heading in soccer is associated with poor cognitive performance only in APOE e4 carriers.https://jamanetwork.com/journals/jamaneurology/fullarticle/2758831 …
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That was one of the most interesting talks in the recent ASHG.https://twitter.com/freeseek82/status/1222029357499265024 …
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Streets all quiet today - can't thank enough our beloved eternal prime minister Netanyahu for shutting down the entire city of Jerusalem for his election propaganda.
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Very cool study of dietary habits in the deeply phenotyped BioBank Japan (n=165k).https://www.nature.com/articles/s41562-019-0805-1 …
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I've written an NIH biosketch for the first time in two years (I don't usually apply to their grants). Glad to report that a lot has changed. But it took SO long and is SO annoying. Does anyone ever read the "Contribution to Science"? What's wrong with top 10 relevant papers?
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Twin study and GWAS of potato chips preference (seriously!) Small study but seems solid. Dietary fat perception is variable across people, but is not yet resolved. h^2=10-30%. Wondering what in my genetics makes me dislike potato chips.https://www.biorxiv.org/content/10.1101/2020.01.18.910448v1 …
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Shai Carmi proslijedio/la je Tweet
Latest paper from our group -- review of new methods for inferring positive selection, led by Hussein Hejase and
@ndukler (sorry, paywall).https://www.cell.com/trends/genetics/fulltext/S0168-9525(19)30269-0 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
A method for improving local ancestry inference using pedigree information. (I.e., detecting and fixing inconsistency in estimated ancestry across relatives.) In simulations, errors down by 50%.
@tamar_sofer and others.https://www.nature.com/articles/s41598-019-57039-w …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
A hypothesis in Science: people with chronic diseases are infectious, as bacteria from "dysbiotic" (altered) gut microbiome can be transmitted to others and cause disease. Wondering what people think. Plausible or unnecessary stigmatization?https://science.sciencemag.org/content/367/6475/250 …
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Shai Carmi proslijedio/la je Tweet
Ancestral Haplotype Reconstruction in Endogamous Populations using Identity-By-Descent https://biorxiv.org/cgi/content/short/2020.01.15.908459v1 …
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Evaluating the accuracy of education polygenic scores in Hungary. "We replicated previous Estonian findings about increased PGS heritability after the fall of Communism". Cool.https://www.biorxiv.org/content/10.1101/2020.01.13.905034v1 …
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For height and BMI, they concluded that ~2/3 of the reduction in accuracy in Africans is due differences in allele frequency and LD, and the rest is due to differences in heritability and effect sizes. In Asians, frequency+LD explain ~1/3 of the risk reduction. 2/2
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It is known that polygenic scores are far less accurate in non-European populations. New paper from Loic Yengo et al derived a formula to quantify the reduction in accuracy and dissected the contribution of the possible causes. 1/2https://www.biorxiv.org/content/10.1101/2020.01.14.905927v1 …
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I really enjoyed reading this. Very well written explanation of the GWAS on the "non-cognitive" contribution to educational attainment. Clear description of the motivation, key results, implications, and pitfalls.https://twitter.com/kph3k/status/1217605499035758592 …
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This is potentially very useful, allowing the PBWT data structure to change dynamically with continuous data collection.https://twitter.com/zhizhid/status/1217617870957555713 …
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Can report that these illustrations were spectacularly successful! Made the rest of the lesson much easier.
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When did Anatomically Modern Humans migrate out of Africa? A palaeoclimatic analysis suggests a few windows during the past 300ky. The migration that left descendants (~60kya) was likely through the Southern (Arabian) route.https://www.biorxiv.org/content/10.1101/2020.01.12.901694v1 …
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An increase in Native-American ancestry over time in Mexican-Americans. Interesting read.https://www.biorxiv.org/content/10.1101/2020.01.13.905141v1 …
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This is amazing. Perfect timing as I am teaching this tomorrow! Curious whether the students will like it.https://twitter.com/allison_horst/status/1216411185240690688 …
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