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Prikvačeni tweet
#WhyIWrite... to share#biotech knowledge I wish I had in#gradschool, and in doing so I learn more about my own industryHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Very cool work showing changes in GPCR ligand binding site can result in biased downstream signaling --> A structural basis for how ligand binding site changes can allosterically regulate
#GPCR signaling and engender functional selectivity@scisignalhttps://stke.sciencemag.org/content/13/617/eaaw5885 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Novel compound is promising drug candidate for
#Alzheimer's disease https://eurekalert.org/e/9qgv via@rpinews@EurekAlert Orig article: Substrate Interaction Inhibits γ-secretase Production of Amyloid-β Peptides --> https://pubs.rsc.org/en/content/articlelanding/2020/cc/c9cc09170j#!divAbstract …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Rob Shaffer proslijedio/la je Tweet
How much does it cost to bootstrap a gene therapy startup? Not too much if you're Jim Wilson, per Passage Bio's $125M IPO filinghttps://endpts.com/how-much-does-it-cost-to-bootstrap-a-gene-therapy-startup-not-too-much-if-youre-jim-wilson-per-passage-bios-125m-ipo-filing/ …
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APOE4 is known AD risk factor, while APOE2 is thought to be protective. Here, better defined (lack of) risk for APOE2 --> Exceptionally low likelihood of
#Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study@NatureComms https://rdcu.be/b08GcHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Rob Shaffer proslijedio/la je Tweet
10 years ago today Wakefield's fraudulent paper was retracted. Not just wrong - fraudulent. It's hard to wrap our heads around the damage done by one person seeking to profit from his lies. So many have died from preventable illness. Trust experts, not frauds.
#VaccinesWorkpic.twitter.com/krUexFcvmT
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Rob Shaffer proslijedio/la je Tweet
Hospital care is the single largest component of U.S.
#healthcare spending, representing one-third of the total. https://freopp.org/affordable-hospital-care-through-competition-and-price-transparency-765714c69ed8 …pic.twitter.com/932eFxcayL
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Rob Shaffer proslijedio/la je Tweet
My general take is that calling any drug an “X-generated” drug, where X is a particular technique or idea is simplistic at the very least and likely misleading. It takes a village of methods and modalities to create an actual drug.https://twitter.com/Dereklowe/status/1223249943701393409 …
Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Five Reasons Why
#Biotech Startups Fail: How to Avoid Themhttps://www.labiotech.eu/startups/biotech-startups-failure-advice/ …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Makes me wonder about the integrity of these junctions during
#neurodegenerative disease progression --> Microglia monitor and protect neuronal function through specialized somatic purinergic junctions@sciencemagazinehttps://science.sciencemag.org/content/367/6477/528 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Great article for those interested in the
#drugprice debate --> Understanding the Rewards of Successful Drug Development — Thinking Inside the Box |@NEJMhttps://www.nejm.org/doi/full/10.1056/NEJMhpr1911004#.XjMrURGIkj4.twitter …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
The Utility of Physicochemical Properties for the Prediction of Toxicological Outcomes: A Takeda perspective.
@acsmedchemletthttps://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00536?utm_source=SendGrid_ealert&utm_medium=ealert&utm_campaign=JAM_amclct&ref=SendGrid_ealert_JAM_amclct#.XjL_TKW2QxE.twitter …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Last week I wrote about a not-new but valuable database (https://projectalpha.mit.edu/ ) that provides historical
#clinicaltrial success rates. Useful info for any and all#biotech stakeholders -->https://twitter.com/ShafferBiotech/status/1221128480181620736 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Inhibiting astrocytic UPR prevents synapse + neuronal loss in
#prion-diseased mice; I wonder if that exacerbates toxic protein accumulation long term? Interesting article@neurocellpress https://bit.ly/37Qpt6Z Commentary@ScienceTMhttps://bit.ly/2t9hz9qHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
"High suPAR levels associated with acute kidney injury" and "Pretreatment with a uPAR mAb attenuated kidney injury in suPAR-overexpressing mice and normalized bioenergetic changes in HK-2 cells" | Soluble Urokinase Receptor and Acute Kidney Injury |
@NEJMhttps://www.nejm.org/doi/full/10.1056/NEJMoa1911481#.XjLaJavofJo.twitter …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Rob Shaffer proslijedio/la je Tweet
If you wonder why everyone's panties are in a twist about novel coronavirus when it's killing far fewer people than seasonal influenza, this story is for you. The answer is a viral sweet spot & its potentially very bad. w
@RobertLangreth@ArmstrongDrewhttps://www.bloomberg.com/news/articles/2020-01-29/viral-sweet-spot-raises-fears-coronavirus-will-be-hard-to-stop …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
"Hope and hype are apparently much more effective tools to drive up price tags than later-stage data, which might inconveniently reveal the true value of an asset" --> Cash-rich biotechs turn down the licensing deal volume https://bit.ly/2U8JvW2 via
@VantageanalysisHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Rob Shaffer proslijedio/la je Tweet
Trying to figure out why toxic aggregates that accumulate in neurodegenerative diseases such as
#ALS are not cleared out by selective#autophagy? https://bit.ly/38FAxnc@MolecularCell Liquidity Is a Critical Determinant for Selective Autophagy of#ProteinCondensatespic.twitter.com/MUAqy9D772
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I was accepted to and can't wait to start the Business of Biotechnology short course (https://www.racap.com/courses/ ) offered by RA Capital and taught by
@PeterKolchinsky. His new book was on my reading list already, but I better move it to the top of the list!Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Rob Shaffer proslijedio/la je Tweet
The protein tau is a major player in neurodegenerative diseases like
#Alzheimers, but a new study shows that it might also prevent brain tumors called#gliomas from transitioning into a more aggressive form.@CBMSO_CSIC_UAMhttps://fcld.ly/873hja8Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Rob Shaffer proslijedio/la je Tweet
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@UWMedicine researchers have discovered a DNA sensing pathway that defends against#viruses in human cells and acts independently of the protein STING, the well-known DNA sensor. This pathway is not present mouse cells. https://fcld.ly/bte45m4 New in@SciImmunology.pic.twitter.com/RC7L6AaJtW
Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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