Rob Shaffer

@ShafferBiotech

Dad, Husband, Biochem PhD, Scientist and Investor | Opinions strictly my own, not investment advice

Vrijeme pridruživanja: rujan 2018.

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  1. Prikvačeni tweet
    19. lis 2018.

    ... to share knowledge I wish I had in , and in doing so I learn more about my own industry

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  2. Very cool work showing changes in GPCR ligand binding site can result in biased downstream signaling --> A structural basis for how ligand binding site changes can allosterically regulate signaling and engender functional selectivity

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  3. 3. velj

    Novel compound is promising drug candidate for 's disease via Orig article: Substrate Interaction Inhibits γ-secretase Production of Amyloid-β Peptides -->

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  4. proslijedio/la je Tweet
    3. velj

    How much does it cost to bootstrap a gene therapy startup? Not too much if you're Jim Wilson, per Passage Bio's $125M IPO filing

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  5. 3. velj

    APOE4 is known AD risk factor, while APOE2 is thought to be protective. Here, better defined (lack of) risk for APOE2 --> Exceptionally low likelihood of ’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study

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  6. proslijedio/la je Tweet
    2. velj

    10 years ago today Wakefield's fraudulent paper was retracted. Not just wrong - fraudulent. It's hard to wrap our heads around the damage done by one person seeking to profit from his lies. So many have died from preventable illness. Trust experts, not frauds.

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  7. proslijedio/la je Tweet
    31. sij

    Hospital care is the single largest component of U.S. spending, representing one-third of the total.

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  8. proslijedio/la je Tweet
    31. sij

    My general take is that calling any drug an “X-generated” drug, where X is a particular technique or idea is simplistic at the very least and likely misleading. It takes a village of methods and modalities to create an actual drug.

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  9. 31. sij
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  10. 31. sij

    Makes me wonder about the integrity of these junctions during disease progression --> Microglia monitor and protect neuronal function through specialized somatic purinergic junctions

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  11. 30. sij

    Great article for those interested in the debate --> Understanding the Rewards of Successful Drug Development — Thinking Inside the Box |

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  12. 30. sij
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  13. 30. sij

    Last week I wrote about a not-new but valuable database () that provides historical success rates. Useful info for any and all stakeholders -->

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  14. 30. sij

    Inhibiting astrocytic UPR prevents synapse + neuronal loss in -diseased mice; I wonder if that exacerbates toxic protein accumulation long term? Interesting article Commentary

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  15. 30. sij

    "High suPAR levels associated with acute kidney injury" and "Pretreatment with a uPAR mAb attenuated kidney injury in suPAR-overexpressing mice and normalized bioenergetic changes in HK-2 cells" | Soluble Urokinase Receptor and Acute Kidney Injury |

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    If you wonder why everyone's panties are in a twist about novel coronavirus when it's killing far fewer people than seasonal influenza, this story is for you. The answer is a viral sweet spot & its potentially very bad. w

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  17. 29. sij

    "Hope and hype are apparently much more effective tools to drive up price tags than later-stage data, which might inconveniently reveal the true value of an asset" --> Cash-rich biotechs turn down the licensing deal volume via

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  18. proslijedio/la je Tweet
    28. sij

    Trying to figure out why toxic aggregates that accumulate in neurodegenerative diseases such as are not cleared out by selective ? Liquidity Is a Critical Determinant for Selective Autophagy of

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  19. 28. sij

    I was accepted to and can't wait to start the Business of Biotechnology short course () offered by RA Capital and taught by . His new book was on my reading list already, but I better move it to the top of the list!

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    The protein tau is a major player in neurodegenerative diseases like , but a new study shows that it might also prevent brain tumors called from transitioning into a more aggressive form.

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  21. proslijedio/la je Tweet

    . researchers have discovered a DNA sensing pathway that defends against in human cells and acts independently of the protein STING, the well-known DNA sensor. This pathway is not present mouse cells. New in .

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