Now for the deets:
We knew from work by @Huda_Akil1 that Mineralocorticoid receptors (MRs) were highy expressed in hippocampal CA2. (@sfarris721 confirmed mRNA #splicejam , also true in human via @AllenInstitute )pic.twitter.com/xZQANYGS6x
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Now for the deets:
We knew from work by @Huda_Akil1 that Mineralocorticoid receptors (MRs) were highy expressed in hippocampal CA2. (@sfarris721 confirmed mRNA #splicejam , also true in human via @AllenInstitute )pic.twitter.com/xZQANYGS6x
POSTBAC extraordinaire @DannyLustberg discovered that knockout of MR (be it prenatal, postnatal targeted to CA2, or in adult) led to loss of CA2 markers. CA1 markers invade. (Thanks also to @TheQuinnLab !)pic.twitter.com/ljYwwLqykH
...now “CA2” looks a whole lot more like CA1 or CA3 (@kelly32123 found the normal LTP-resistance in CA2 is gone).pic.twitter.com/oYJK0vVKqS
Other amazing lab peeps not on Twitter found that CA2-targeted MR KOs had deficits in social discrimination and hyper-reactivity to novelty, much like what has been described using a CaMKII crepic.twitter.com/fWNLR0GnGB
And wouldn’t you know? This past summer, another group identified structural variants affecting non-coding regions of NR3C2 in a syndromic form of autism #Autism #ASDhttps://www.cell.com/cell/fulltext/S0092-8674(19)30780-9 …
exciting year of papers for your lab!!
CA2ness! 

Happy to see Danny’s efforts come to fruition!
Nice to see this out! great work!!
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