Does anyone have any information on how the front line healthcare workers who have been taking hydroxychloroquine prophylactically are doing? Has even one of them gotten the virus? And if so, did it require hospitalization?
Would it be safe to say, based on the fact that no trials have ended early, that they are seeing no clear benefits?
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No. It’d be safer to say that there’s no slam dunk large benefit. Smaller benefits could emerge if power calculations used to design the study were accurate (usually are). Trials stop early when drug exceeds even those expectations. Like the reverse of a mercy rule in ping pong.
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Asking another way, can we rule out "game changer"?
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