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German researchers provide experimental evidence suggesting the direct involvement of various forms of truncated forms of
#Parkinsons-associated alpha synuclein in differential seeding activities; might be relevant for differential strain formation & fate https://www.nature.com/articles/s41419-020-2285-7 …pic.twitter.com/9Ail5E9MUz
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Cholinesterase inhibitor, Rivastigmine, modifies the α-secretase pathway & potentially early
#Alzheimers. It "can modify the levels of several shedding proteins & directs APP processing toward the non-amyloidogenic pathway" https://www.nature.com/articles/s41398-020-0709-x …pic.twitter.com/Do68ztXJGM
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Interesting discussion of Ferroptosis: past, present & future;
#Parkinsons gets a mention https://www.nature.com/articles/s41419-020-2298-2 …pic.twitter.com/hTT4YZVGcE
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ScienceofParkinsons proslijedio/la je Tweet
Innate immune monocyte markers altered in
#Parkinson, and accompanied by elevated serum bacterial endotoxin. Particularly pronounced in Parkinson cases at higher#Dementia risk.#Innateimmunity again.#Pathogens ? https://www.sciencedirect.com/science/article/pii/S0889159119312619?via%3Dihub …pic.twitter.com/6VWyNVygmB
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Interesting discussion with
@Kieran_Research - "If companies want to license a new drug, will they submit the marketing authorisation application to the European Medicines Agency (EMA), which is around 600 million people, or submit it to the UK, which is 60 million people?"https://twitter.com/parkinsons_life/status/1224014822720921602 …
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ScienceofParkinsons proslijedio/la je Tweet
Fascinating discussion on the relevance LOF and GOF mechanisms in AD/PD by
@Kariem_Ezzat@AlbertoEspay and others. Could all of the#Parkinson KOLs please also spare a thought on role of membrane lipids in the below discussion? https://twitter.com/randomchaos8/status/1212841672217956353?s=21 …https://twitter.com/kariem_ezzat/status/1223310010450632705 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
"IFN-γmay serve as the central regulator of LRRK2-mediated responses during infections & immunity, as well as neuroinflammatory processes in a cell-type specific manner"
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OTU deubiquitinase ubiquitin aldehyde binding 1 (OTUB1) - a deubiquitinating enzyme - has been associated with
#Parkinsons &#Alzheimers. New study suggests OTUB1 may contribute to lewy body pathology through its amyloidogenic properties https://www.jbc.org/content/early/2020/01/31/jbc.RA119.009546 …pic.twitter.com/3KdhDUTyhV
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Interesting - embryonic ablation of Mesencephalic astrocyte-derived neurotrophic factor (MANF) causes prolonged activation of the unfolded protein response, but does NOT cause the loss of midbrain dopamine neurons in mice. https://www.eneuro.org/content/early/2020/01/31/ENEURO.0477-19.2019 …pic.twitter.com/0eMi9ofhH3
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Interesting: "bacterial translocation associated changes may contribute towards progression to
#Parkinsons dementia" - potential biomarker?Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
The protocol of the INfusion VErsus STimulation (INVEST) study has been published. This is a randomized open label multicentre trial comparing continuous intrajejunal levodopa infusion with deep brain stimulation in
#Parkinsons (NCT02480803). https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-020-1621-y …pic.twitter.com/HIj5xSKR9v
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ScienceofParkinsons proslijedio/la je Tweet
In a crisis, we turn to real-time
#openscience.@bubela_tania mused: if we know secrecy/patent-driven science cannot deliver when it really matters, why do our innovation policies endorse it? Don't we want to speed up finding#Alzheimers cures too?https://www.cbc.ca/news/health/coronavirus-2019-ncov-science-virus-genome-who-research-collaboration-1.5446948 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Polish researchers report impact of subthalamic-deep brain stimulation on UPDRS III OFF score & cognitive alterations suggest a neuromodulatory role (mainly during the first 9–18 months after surgery)https://www.jocn-journal.com/article/S0967-5868(19)31893-4/fulltext …
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Fascinating read in many diff. ways - recommended weekend reading! "[They say] we're opening everything because it's important that we advance things fast. Well, the flip side of this argument is that your normal behaviour is to put barriers to science" -
@larivievhttps://twitter.com/aledmedwards/status/1223607754440482823 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Interesting - a case study of an individual with
#Parkinsons who was transplanted (at age 49yrs) with fetal tissue reports the co-existence of Tau & α-synuclein pathology in the grafted cells at autopsy (at age 70yrs)... but only in the left-side graft?!?https://www.prd-journal.com/article/S1353-8020(19)30532-2/fulltext …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Chinese researchers report that deletion of Autophagy related 5 (Atg5 - a key player in autophagy) in microglia causes
#Parkinsons-like symptoms & loss of dopamine neurons in mice, via NLRP3 inflammasome activation. NLRP3 inhibitor MCC950 rescued situationhttps://www.tandfonline.com/doi/abs/10.1080/15548627.2020.1719723 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
ScienceofParkinsons proslijedio/la je Tweet
Coming soon, and written by a PD dream team: Ray Dorsey
@UofR, Todd Sherer@MichaelJFoxOrg, Michael Okun@UFHealth@ParkinsonDotOrg, and Bastiaan Bloem@basbloem@radboudumc
pic.twitter.com/KZRaooHTfn
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ScienceofParkinsons proslijedio/la je Tweet
Does sporadic young-onset Parkinson’s have a lysosomal root?
#Alzforum@CedarsSinai http://ow.ly/Js3f50yaDjj pic.twitter.com/oSu9ieIFbU
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New word for me: Macropinocytosis It is a specialized form of endocytosis in macrophages.
@Duke_Neurology researchers have a@biorxivpreprint manuscript suggesting Rab10 is a primary effector of macropinocytosis, &#Parkinsons-associated LRRK2 is involved https://www.biorxiv.org/content/10.1101/2020.01.30.926840v1 …pic.twitter.com/xkALuWLCKC
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