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Feb 1

The new issue of #ScienceTranslationalMedicine has arrived! Scientists study why a macular degeneration drug can cause retinal side effects, a Viewpoint explores the promise and challenges of smart toilets for precision health, and more. scim.ag/1ng

Feb 4

In a new Focus, researchers discuss how #SmartToilets could help collect a wide range of health-related data—while also examining technical, cultural, and ethical challenges to their implementation. scim.ag/1pj

@Stanford

@StanfordMed

Feb 1

Ready for a smart toilet? 😉 science.org/doi/10.1126/sc

I'm not. But it could be a good research tool for data collection for willing participants

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Feb 3

Researchers present a new bispecific nanobody that can simultaneously target and inhibit both TNF and IL-6 in #RheumatoidArthritis, offering stronger anti-RA effects in culture than traditional monotherapies.

@sanofi

scim.ag/1oY

#MedicalDevice scim.ag/1oC

Feb 3

A lightweight, portable #SoftRobotic assistive device from the

@walshharvard

lab supports shoulder and arm movements in patients with #ALS, leading to reduced muscle exertion and the ability to accomplish tasks of daily living.

@hseas

Seung-min Park

@SeungminPark_

Feb 2

I am excited to share a new story about smart toilets out today in

with amazing colleagues,

, and

. Smart toilets are a key tool for enabling precision health monitoring in the home.

Passive monitoring by smart toilets for precision health

Smart toilets are a key tool for enabling precision health monitoring in the home, but such passive monitoring has ethical considerations.

#MachineLearning scim.ag/1mg

Jan 31

Researchers present a digital workflow of virtualized brains tailored to patients with drug-resistant #epilepsy, allowing researchers to precisely map out epileptogenic brain zones and potentially guide surgical interventions.

@univamu

Jan 27

Profiling #malaria immunity in Ugandan children, the

@pjagannathanlab

shows a distinct population of #NaturalKillerCells expands after repeated exposure and correlates with lower parasite loads and protection against symptoms.

@IDRC_Uganda

@prasannaj77

scim.ag/1jO

Jan 26

The #ALDH2 alcohol flushing variant impairs vascular function in humans and cells by eliciting inflammation in the #endothelium, shows a genome-wide analysis that examines the link between the variant and #CoronaryArteryDisease.

@Joseph_C_Wu

@StanfordCVI

scim.ag/1jb

Shout out to

for publishing our study describing how clinical immunity to malaria is linked to "high-maintenance" CD56-negative NK cells! 1/n

@pjagannathanlab

Quote Tweet

Jan 25

Research links anti-malaria immunity in children to "high-maintenance" natural killer cells, how an alcohol flushing gene variant may raise the risk of coronary artery disease, and more in this week's issue of #ScienceTranslationalMedicine. scim.ag/1if

Jan 25

Jan 24

A compound that targets de novo lipid synthesis in #GliomaStemCells shrinks #glioblastoma tumors in mice, potentiates DNA-damaging agents, and can penetrate the blood-brain barrier.

@katharinaeyme

@BadRlab

@ale_samma

Read more: scim.ag/1hq

Jan 23

Applying a #DrugDiscovery pipeline, researchers identify a drug candidate for #ParkinsonsDisease that halts neurodegeneration and restores motor function in mice with inherited or sporadic disease.

Jan 21

Catheters can trigger resurgence of #UrinaryTractInfections due to #Abaumanii in mice recovered from infection—hinting the bacteria may form bladder reservoirs capable of reinfection.

Jan 20

Leveraging an epigenomic editing approach, researchers correct defects in neurons linked to #RettSyndrome by demethylating and reactivating the wild-type MECP2 gene on the inactive X chromosome.

@ShawnLiu_Lab

@ColumbiaPHY

#Epigenetics scim.ag/1f6

Jan 20

In this week’s #SciencePodcast🎙️,

@boron110

and Kari Nadeau dive into a #ScienceTranslationalMedicine Review exploring the science of #allergies and how discoveries about diet, allergens, and the microbiome are redefining treatment and prevention. 🎧: scim.ag/1eR

GIF

Jan 20

A compound that targets de novo lipid synthesis in #GliomaStemCells shrinks #glioblastoma tumors in mice, potentiates DNA-damaging agents, and can penetrate the blood-brain barrier. Read more: scim.ag/1eG

@katharinaeyme

@BadRlab

@ale_samma

Shawn Liu

@ShawnLiu_Lab

Jan 19

Excited to share our recent paper on application of our epigenome editing tools to tackle neurodevelopmental disease. A few points we learned are listed below. Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons

Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons

Reactivation of MECP2 from the inactive X chromosome by multiplex epigenome editing rescues Rett syndrome neurons in vitro.

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Jan 19

A population of CD200-expressing, tumor-infiltrating #Tcells may help predict how patients with various types of #cancer respond to #PDL1 checkpoint blockade #immunotherapy, suggests a paper based on mice and patient samples. scim.ag/1e9

Jan 18

This week's new issue of #ScienceTranslationalMedicine has arrived! Tumor-infiltrating T cells offer clues about predicting responses to cancer immunotherapy, a study in mice highlights a potential treatment for Parkinson's disease, and more. scim.ag/1d3

Sara Di Simone

@SaraDiSimone3

Jan 15

Check out our new latest review in

. science.org/doi/pdf/10.112

on respiratory microbiome-immune system interactions in health and disease

@NoldLab

and

@_sam_forster_

Jan 11

Cell-free DNA fragmentation patterns and sequencing from small amounts of plasma hold considerable promise for screening and early detection of cancer science.org/doi/10.1126/sc

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Jan 16

Catheters can trigger resurgence of #UrinaryTractInfections due to #Abaumanii in mice recovered from infection—hinting the bacteria may form bladder reservoirs capable of reinfection.

Jan 14

A new detection technique for small-cell lung cancer (#SCLC) that searches for disease-linked autoantibodies could address the need for a feasible test for earlier diagnosis in patients with this aggressive #cancer, show researchers at

@fredhutch

. scim.ag/1aq

Jan 13

A machine learning platform for #CancerTesting that analyzes fragmentation patterns in #cfDNA can distinguish patients with cancer with a high degree of accuracy, according to a new study from the

@MurtazaMDPhD

lab involving 2,600+ samples.

@WiscSurgery

scim.ag/1a2

M Murtaza

@MurtazaMDPhD

Jan 12

Happy to share our new

paper. It turns out simply measuring plasma DNA fragments that break at unexpected positions across the genome holds promise as a cancer biomarker for detection and monitoring

Genome-wide analysis of aberrant position and sequence of plasma DNA fragment ends in patients with...

Analyzing the positioning and nucleotide frequency at plasma DNA fragment ends can improve cancer detection.

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Jan 13

The submission deadline is approaching for the 2023

@AAAS

Martin and Rose Wachtel Cancer Research Award for young investigators. Apply by 1 February 2023: scim.ag/19v

Jan 11

Some #SARSCoV2 mutations that confer resistance to Paxlovid have been deposited

@NCBI

@GISAID

science.org/doi/10.1126/sc

"Our findings argue for highly selective use...because extensive, unselective use is expected to rapidly lead to emergence of drug resistance."

1,019

1,548

Jan 11

The new issue of #ScienceTranslationalMedicine has arrived! Fragment patterns in tumor DNA inform cancer diagnostics, a predictive model may detect small-cell lung cancer, a Report shows catheters can trigger dormant UTIs in mice, and more. scim.ag/186

Jan 9

A study of #NonAlcoholicSteatohepatitis in mice reveals a circuit of 60+ receptor-ligand interactions that drive liver #fibrosis, offering a compendium of potential therapeutic targets.

Shuang Wang (Sammi)

@SammiShuang

Jan 7

My second first-author paper is out from my postdoc - check it out on the cover of Jan4th issue of

Icahn School of Medicine at Mount Sinai

! So grateful for my postdoc mentors

@scottfriedmanmd

and Kirsten Sadler Edepli!! 🙏 Super excited to launch the next phase of my career - stay tuned! 🌊🌊🌊

Quote Tweet

@IcahnMountSinai

Jan 7

New candidate drug targets for non-alcoholic fatty liver disease (NAFLD) were discovered through single-nuclear sequencing and advanced 3D glass imaging at the Icahn School of Medicine at Mount Sinai. Learn more: mshs.co/3ZhHw0F

Jan 7

Engineering live tumor cells to secrete IFN-beta and GM-CSF, the

@khalidshahs

lab presents a #CancerVaccine that safely and directly targets tumors and stimulates antitumor immunity in mice with #glioblastoma. @cks1988

@BrighamWomens

scim.ag/15w

Jan 4

“Our results highlight the importance and feasibility of a universal vaccine to fight against SARS-CoV-2 antigenic drift.”

Vaccination with Span, an antigen guided by SARS-CoV-2 S protein evolution, protects against...

The evolution of the SARS-CoV-2 S protein guided the design of a pan-vaccine antigen, Span, to combat SARS-CoV-2 antigenic drift.

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Jan 6

A #microdystrophin #GeneTherapy for Duchenne muscular dystrophy proves safe and shows promise in large animals, suggesting it could address obstacles with vector capacity and delivery of genes for this severe condition.

@tamuvetmed

@barrybyrne1

scim.ag/155

Jan 5

Taking inspiration from the evolutionary history of #SARSCoV2, scientists have designed a new vaccine with a universal spike protein antigen that combats antigenic drift and can protect mice from #Omicron, Delta, and other variants.

@WHUni_Official

scim.ag/14a

Jan 4

This year's first issue of #ScienceTranslationalMedicine has arrived! The evolutionary history of SARS-CoV-2 informs a broadly protective vaccine candidate, an experimental gene therapy for muscular dystrophy shows promise in large animals, and more. scim.ag/13x

Dec 30, 2022

Long-term smell loss (#anosmia) after #COVID19 may be linked to perturbations in immune cells and a persistent T cell inflammatory response in olfactory epithelia, shows an analysis of patient biopsies from the

@goldstein_brad

lab.

@DukeMSTP

scim.ag/11u

Dec 29, 2022

New work from

@OACentreOxford

demystifies the link between #osteoarthritis in patients and variants in the gene ALDH1A2, and show that a blocker of #RetinoicAcid metabolism can suppress inflammatory genes and cartilage injury in mice. scim.ag/10S

#InfectiousDisease scim.ag/Yp

Dec 25, 2022

An adenovirus-based vaccine for #MarburgVirus rapidly protects large animals from severe infection with protection lasting up to 1 year—supporting its potential as a tool for outbreak control and pandemic preparedness.

@NIAIDNews