Scacheri Lab

@ScacheriLab

Epigenetics and human disease research lab at Case Western Reserve University School of Medicine -- Department of Genetics & Genome Sciences

Vrijeme pridruživanja: svibanj 2014.

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  1. Prikvačeni tweet
    21. stu 2019.

    1/ So excited to have our work joint with the Rich lab lead by published in Cell today: “Functional enhancers shape extrachromosomal oncogene amplifications”. below

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  2. 23. sij

    A must read. Great work from Lupien Lab.

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  3. proslijedio/la je Tweet
    21. pro 2019.

    Check out our first preprint! Together with we show that MYCN amplicon structure is not only determined by local enhancers , as shown by but that chimeric amplicons can recruit distal enhancers leading to enhancer hijacking.

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  4. proslijedio/la je Tweet
    27. stu 2019.

    Here’s a link to read and download for those without a subscription. Check it out!

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  5. 21. stu 2019.

    ecDNA is hot! We encourage you to also read yesterday’s paper lead by Bing Ren and Vineet Bafna.

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  6. 21. stu 2019.

    8/ Many thanks to all of our fabulous collaborators, , Stephen Mack , , , , Brian Rubin, Shashi Shetty and all the other co-authors.

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  7. 21. stu 2019.

    7/ Looking at focal amplifications across 7 different cancers, we found that enhancer selection is common. The enhancers are often active in the tissue of origin. This suggests that these enhancers were present when the amplification first arose.

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  8. 21. stu 2019.

    6/ We show through a CRISPRi screen that nearly all of the co-opted enhancers contribute to glioblastoma growth. This indicates that not just the oncogene, but the entire locus i.e. the “onco-locus” is a driver.

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  9. 21. stu 2019.

    5/ We see massive rewiring of the chromatin topology on the ecDNA. Compared to the unamplified locus (top), amplified EGFR (bottom) co-opts nearly all neighboring enhancers, even those beyond the TAD boundary!

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  10. 21. stu 2019.

    4/ EGFR amplifications occur as circular extrachromosomal DNA (ecDNA), which are common across many types of cancer. We see that the ecDNA amplifications are loaded with regulatory elements.

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  11. 21. stu 2019.

    3/ Focusing initially on glioblastoma, we found that a non-coding region upstream of EGFR is nearly always co-amplified with the gene. This region contains two enhancers elements that regulate EGFR.

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  12. 21. stu 2019.

    2/ Oncogene amplifications are common across cancers and frequently carry along non-coding DNA sequences. We find that these sequences undergo selection.

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  13. 18. stu 2019.

    Say hello our lab’s latest piece of equipment! Many thanks to Liz Menges . This will help us in our search for a cure.

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  14. 15. stu 2019.

    Congrats to Lupien Lab on this groundbreaking study. Like others from the Lupien lab, it is ahead of its time.

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  15. proslijedio/la je Tweet
    17. lis 2019.

    If you are attending , look out for members of the Human Molecular Genetics editorial board to discuss your work and possibility of submitting to the journal. Review the list to look out for these editors:

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  16. 17. lis 2019.

    attendees. Come say hello to us at the CWRU/Cleveland Clinic Reception at 8:30 pm in the Marriott. This is not a private event so feel to drop by for a drink.

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  17. 16. lis 2019.

    What’s up with all that “extra” DNA that gets co-amplified with oncogenes in cancer? Come find out at Andrew Morton’s Platform talk. Today at 5pm in Grand Ballroom A.

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  18. proslijedio/la je Tweet
    19. ruj 2019.

    Genomes consist of different types of clusters, such as , , island, and . Here is our latest method to identify COREs (Clusters Of cis-Regulatory Elements) using ⁦⁩ data. Thanks to ⁦⁦⁦

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  19. 9. ruj 2019.

    Our latest is out! Awesome collaboration with George Lab . We developed an approach to screen for drugs that inhibit osteosarcoma cells from growing in the lung, where they metastasize. CDK12 inhibitors are especially effective.

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  20. proslijedio/la je Tweet
    31. srp 2019.

    Our study now . Influence of dietary methionine on systemic and cellular metabolism in mice humans. Effects on cancer and interactions with cancer therapies. Congratulations everyone!

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