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Prikvačeni tweet
1/ So excited to have our work joint with the Rich lab lead by
@morton_andrew published in Cell@CellCellPress today: “Functional enhancers shape extrachromosomal oncogene amplifications”. https://www.cell.com/cell/fulltext/S0092-8674(19)31216-4 …#tweetorial belowPrikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
A must read. Great work from Lupien Lab.https://twitter.com/MatLupien/status/1220400988680544256 …
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Scacheri Lab proslijedio/la je Tweet
Check out our first preprint! Together with
@RichardKoche@CMskcc we show that MYCN amplicon structure is not only determined by local enhancers , as shown by@ScacheriLab@CellCellPress but that chimeric amplicons can recruit distal enhancers leading to enhancer hijacking. https://twitter.com/biorxiv_cancer/status/1208164487959896065 …Tweet je nedostupan.Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Scacheri Lab proslijedio/la je Tweet
Here’s a link to read and download for those without a subscription. Check it out! https://authors.elsevier.com/c/1a8FUL7PXYX0a https://twitter.com/ScacheriLab/status/1197542531061317632 …
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ecDNA is hot! We encourage you to also read yesterday’s
@nature paper lead by@mischellab@HowardYChang Bing Ren and Vineet Bafna.https://www.nature.com/articles/s41586-019-1763-5 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
8/ Many thanks to all of our fabulous collaborators,
@MatLupien , Stephen Mack ,@StephAngers ,@BrainSurgn1989 ,@axiotlinc , Brian Rubin, Shashi Shetty and all the other co-authors.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
7/ Looking at focal amplifications across 7 different cancers, we found that enhancer selection is common. The enhancers are often active in the tissue of origin. This suggests that these enhancers were present when the amplification first arose.pic.twitter.com/PziGJ5BH8P
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6/ We show through a CRISPRi screen that nearly all of the co-opted enhancers contribute to glioblastoma growth. This indicates that not just the oncogene, but the entire locus i.e. the “onco-locus” is a driver.pic.twitter.com/DAawwG1Ny3
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5/ We see massive rewiring of the chromatin topology on the ecDNA. Compared to the unamplified locus (top), amplified EGFR (bottom) co-opts nearly all neighboring enhancers, even those beyond the TAD boundary!pic.twitter.com/hezkwoTgHB
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4/ EGFR amplifications occur as circular extrachromosomal DNA (ecDNA), which are common across many types of cancer. We see that the ecDNA amplifications are loaded with regulatory elements.pic.twitter.com/k86jDqk2ZR
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3/ Focusing initially on glioblastoma, we found that a non-coding region upstream of EGFR is nearly always co-amplified with the gene. This region contains two enhancers elements that regulate EGFR.pic.twitter.com/mI36O2ICOT
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2/ Oncogene amplifications are common across cancers and frequently carry along non-coding DNA sequences. We find that these sequences undergo selection.pic.twitter.com/x43z6QwonZ
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Say hello our lab’s latest piece of equipment! Many thanks to Liz Menges
@EMenges430. This will help us in our search for a cure.#EspressoLovepic.twitter.com/jEqmmCNHQt
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Congrats to Lupien Lab on this groundbreaking study. Like others from the Lupien lab, it is ahead of its time.https://www.cell.com/cancer-cell/fulltext/S1535-6108(19)30479-9#.Xc8M-G4-jCQ.twitter …
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Scacheri Lab proslijedio/la je Tweet
If you are attending
#ASHG19, look out for members of the Human Molecular Genetics editorial board to discuss your work and possibility of submitting to the journal. Review the list to look out for these editors: http://bit.ly/32r7fpJ http://bit.ly/2oDrySlHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
#ASHG19 attendees. Come say hello to us at the CWRU/Cleveland Clinic Reception at 8:30 pm in the Marriott. This is not a private event so feel to drop by for a drink.Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
What’s up with all that “extra” DNA that gets co-amplified with oncogenes in cancer? Come find out at Andrew Morton’s
#ASHG19 Platform talk. Today at 5pm in Grand Ballroom A.Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Scacheri Lab proslijedio/la je Tweet
Genomes consist of different types of clusters, such as
#LAD,#TAD,#CpG island,#HCT and#CORE. Here is our latest method to identify COREs (Clusters Of cis-Regulatory Elements) using @ENCODE_NIH data. Thanks to @seyedali_madani http://m.genome.cshlp.org/content/early/2019/09/18/gr.248658.119 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Our latest is out! Awesome collaboration with George Lab
@DanaFarber. We developed an approach to screen for drugs that inhibit osteosarcoma cells from growing in the lung, where they metastasize. CDK12 inhibitors are especially effective. https://www.jci.org/articles/view/127718#.XXa3PJcdWtM.twitter …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Scacheri Lab proslijedio/la je Tweet
Our study now
@nature. Influence of dietary methionine on systemic and cellular metabolism in mice humans. Effects on cancer and interactions with cancer therapies. Congratulations everyone!https://www.nature.com/articles/s41586-019-1437-3 …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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