Possible confound: Greek life?
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"These findings suggest that identifying the as-yet unknown sources of experimental variability among sites should become a high priority until we have sufficient understanding to consistently reproduce experimental results at multiple institutions."
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What are the temperatures they're housed at in each institution, does it say?
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Temperature was the same. May be microbiome????
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Maybe their parents paid more to get them into...
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Light conditions? Cage size?
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Noise levels and cortisol?
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Cage type should be considered. Check out work being done in this lab: http://www.bioacademy.gr/faculty-details/GMM/nikolaos-g …
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Kostomitsopoulos N, Alexakos P, Konsolaki E, Doulou A, Paschidis K, Baumans V. The effect of different types of individually ventilated caging systems on growing male mice. Lab Animal (NY) 2012;41(7):192-197
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The
#MoTrPAC consortium allowed us to do something similar with F344 rats but on a smaller scale. Body weight (especially the more variable males) significantly varied by site Boston rats heavier than Gainesville. -
And same light schedule, same chow, same bedding
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