Sara Nayeem

@SaraNayeem

Partner investing in biopharma; particular areas of interest include & oncology. Also mom to three boys 6 and under!

Vrijeme pridruživanja: rujan 2011.

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  1. Prikvačeni tweet
    11. stu 2019.

    Honored to be included on the 2019 Fiercest Women in Life Sciences list! The writeup touches on several topics around which I feel esp. fierce today-investing in , &speaking about the innovation ecosystem

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  2. proslijedio/la je Tweet

    Now that testing is being expanded to state labs, we’re likely to diagnose more cases and identify some local outbreaks. NYC has some of best public health labs and also many China travelers, and should be able to spot community spread early.

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  3. proslijedio/la je Tweet

    Great work by to take a key step toward being able to expand testing for to state and local public health labs.

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  4. prije 8 sati

    Encouraging to see clinical trials starting with Gilead’s remdesivir, a failed Ebola drug which appeared to help a US patient w/ treated on a compassionate use basis.

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  5. proslijedio/la je Tweet

    Thailand has 25 confirmed cases, Japan 24, Singapore 24. The has continued to spread with Singapore, Malaysia, and Thailand reporting new infections that weren’t imported from China. They now seem to be suffering sustained local transmission.

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  6. proslijedio/la je Tweet

    I don’t know if I’ve seen anyone say this but my heart goes out to the people of China right now. I can’t imagine how scared everyone must be. Thinking of those who have lost loved ones and hope that the many still suffering recover and soon... In China and beyond.

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  7. proslijedio/la je Tweet

    The latest numbers, just released, on the toll in China continues to reveal a grim and worsening epidemic. The total number of cases are 24,324, up more than 3,900 from yesterday. Total deaths now at 490, up another 65 since yesterday.

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  8. prije 18 sati

    Fascinating take on the potential future of the new . Interestingly, the new virus "has a molecular proofreading system that reduces its mutation rate", so it mutates more slowly than flu or HIV; hopefully it won't become much more pathogenic.

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  9. proslijedio/la je Tweet

    Thread: There are now 2 deaths in 146 patients diagnosed with outside China. It’s a case fatality rate of 1.37%. This may be our best estimate to date. The patients include mild disease as well those presenting with pneumonia. It tracks with 2% CFR reported in China.

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  10. proslijedio/la je Tweet

    Even if CFR ends up around 0.5%, Ro 2-3, and 10-20% develop significant pneumonia, this could still burn its way through large populations and become a historic and devastating pandemic. We face a lot of uncertainty, and risk. The next several weeks are critical for containment.

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  11. proslijedio/la je Tweet

    The two new cases in Hong Kong, both in their 60s, had not travelled to mainland China recently, strongly suggesting that community transmission is now established in the city and a broader outbreak may be underway.

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  12. proslijedio/la je Tweet
    3. velj

    Whoa, that NEJM report from Germany claiming asymptomatic transmission of turned out to be wrong The index patient did have symptoms while in Germany. German RKI has written a letter to NEJM to set the record straight

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    and can allow more labs to run the RT-PCR tests starting with public health agencies. Big medical centers can also be authorized to run tests under EUA. For now they're not permitted to run the tests, even though many labs can do so reliably 9/9

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    Since CDC and FDA haven’t authorized public health or hospital labs to run the tests, right now is the only place that can. So, screening has to be rationed. Our ability to detect secondary spread among people not directly tied to China travel is greatly limited.

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  15. proslijedio/la je Tweet

    Terrible turn - “Hong Kong Medical Workers to Strike as Outbreak Worsens.” China has already closed its own cities down. Whether it will work or not is unclear. But if they’ve done it on mainland, why are they preventing Hong Kong from taking same measure?

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  16. proslijedio/la je Tweet

    Screening travelers is prudent but we must take care to support China’s response. The best way to prevent a pandemic is end their epidemic. We must also step up surveillance in U.S. hospitals and not rely on travel history alone as trigger for screening.

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  17. 2. velj

    It should also be noted that the CDC stats from the 2018-2019 flu season indicate a ~0.1% mortality rate from the flu in the US (35.5M cases, 34.2K deaths).

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  18. 2. velj

    ...This may also reflect the fact that in areas of high infection rate, mild cases aren’t being confirmed (limits on # of tests performed), but mild cases may be picked up more in areas with lower infection burden, as well as higher mortality where hospitals are overwhelmed. 4//4

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  19. 2. velj

    ...would result in a higher fatality rate. Of course, it’s early days for looking at data outside of China. Hard to be too precise on fatality rate with a (thankfully) small # of confirmed cases thus far. Even within China, the mortality rate outside Wuhan is much lower. 3/4

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  20. 2. velj

    ...we should expect more fatalities. Another way to look at the fatality rate is vs. the # of dx’d cases at a particular point in the past: deaths at point x / dx’d at point (x - average # of days between dx and death). I won’t hazard that type of analysis myself, but it... 2/4

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  21. 2. velj

    First death from outside of China. Given concerns that China infection #’s exclude mild cases, & that China may also be under-reporting fatalities, we should look ex-US for the true fatality rate. Thus far 1/178, or 0.56%. But given time between dx and death,... 1/4

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