Highlights: (1) Genes essential specifically in mESCs linked to pluripotent state (2) ~30% of human genes intolerant to LoF mutations are essential in mouse or human ESCs (3) The human phenotypes most significantly associated with essential genes in ESCs are neurodevelopmental.
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(4) essential gene with moderate effect are more likely to be associated with human diseases than gene with severe effect on viability. You must be alive to have a disease... https://genome.cshlp.org/content/early/2019/10/24/gr.250019.119.abstract …
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