This paper has just been published on Biorxiv. I would be extremely interested in seeing comment from others working on 2019-nCoV sequencing, because its claims are. . .unusual, to say the least. But presented with data:https://www.biorxiv.org/content/10.1101/2020.01.30.927871v1 …
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Didn’t researchers from Wuhan also publish the first example of bat coronavirus in 2015? Isn’t the gp120 and GAG insertion super sketchy? The linker domain is also sketchy. I will double check the domains to see which portion of HIV’s gp120/GAG domains this came from.
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Thank you, all of you, for checking into this.
@DrEricDing is retweeting this, and it's freaking people out that it's a bioweapon. No one's talking about that this is a pre-print - just the sensationalism. - Još 4 druga odgovora
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The other novel insert between the bat coronavirus glycoprotein and NCoV is more similar to 13 viruses besides HIV and none of those similarities is higher than chance (given insert size/viral protein database size)
- Još 2 druga odgovora
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I am impressed with the level of detail and the knowledge displayed. How about a novice interpretation for us boomers?
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The virus infecting humans is more similar to the bat coronavirus than this paper indicated. And the inserts into its genetic sequence were too short to say that they're coming from HIV - they could be from anywhere.
- Još 2 druga odgovora
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Thanks for looking at this! Can you note which sequences you found in bat coronaviruses and link to these regions? I'm trying to compile claims about coronavirus phylogenetics and this would be helpful!
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inserts HKNNKS and RSYLTPGDSSSG of NCoV glycoprotein compared to SARS are found in spike glycoprotein [Bat coronavirus] (Sequence ID: QHR63300.1). 100% identity.
- Još 3 druga odgovora
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The methods are not well described, there are many flaws here and there, i.e. 1) no genbank references for the HIV sequences they used, 2) the insertions regions are short and hypervariables region, 3) the tree is not rooted by the outgroup.
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It seems they took only the short fragments to perform a blast and found these motif in HIV sequence. But no e-values are provided for the blast results.
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