Sean Cavanagh

@SCavanaghNeuro

PhD student at UCL Institute of Neurology. Interested in how the brain makes decisions.

London
Vrijeme pridruživanja: listopad 2009.

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  1. Prikvačeni tweet
    21. lis 2019.

    Our paper 'Visual fixation patterns during economic choice reflect covert valuation processes that emerge with learning' is out in ! This is work with Nish Malalasekera (joint first author), Bruno Miranda, and Steve Kennerley [1/8]

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  2. proslijedio/la je Tweet
    1. stu 2019.

    We are happy to share our latest work! Big thanks to the 3 reviewers for their insightful comments

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  3. 1. stu 2019.

    The results have important implications for the role of NMDA-R in cognitive function. They also provide insight to the role of the NMDA-R in the pathophysiology of neuropsychiatric disorders such as Schizophrenia.

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  4. 1. stu 2019.

    We then tested these experimentally using the NMDA-R antagonist ketamine - which produced decision making deficits consistent with a lowering of excitation inhibition (E/I) balance.

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  5. 1. stu 2019.

    The circuit relied on NMDA-R activity, and we simulated the effects of NMDA-R hypofunction onto either pyramidal cells or interneurons. These two perturbations made dissociated predictions for behaviour.

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  6. 1. stu 2019.

    We used psychophysics to reveal irrational biases in evidence accumulation decisions. We then used a spiking circuit to reveal a neural mechanism for these biases.

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  7. 1. stu 2019.

    Our new paper, (with Norman Lam, , , and Steve Kennerley is on Biorxiv!

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  8. proslijedio/la je Tweet
    28. lis 2019.

    Our paper on computational noise in reinforcement learning is out today in ()! Co-1st authored by the brilliant and , collab with at . Quick summary: (1/14)

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  9. 21. lis 2019.
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  10. 21. lis 2019.

    Our results suggest that the brain uses fast (150ms) covert mechanisms for guiding fixations toward highly valuable and novel information. By employing such covert mechanisms, fixation behavior becomes dissociable from the value comparison processes that drive choices [8/8]

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  11. 21. lis 2019.

    Finally, we confirmed our subjects were making choices with a similar decision mechanism to previous human studies. We showed that how long a stimulus was fixated influenced its likelihood of being chosen [7/8]

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  12. 21. lis 2019.

    A further dissociation between fixations and choices was shown on Mixed trials (overtrained vs. novel stimulus) - there was a strong bias toward fixating the novel stimulus first, but no bias toward choosing it [6/8]

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  13. 21. lis 2019.

    For novel stimuli, 1st fixations became more value-driven across a session – as subjects gained more experience of the stimuli. However, this improvement lagged behind learning of accurate choices, suggesting separate processes governed the learning of fixations and choices [5/8]

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  14. 21. lis 2019.

    The first fixation latency was fast (∼150 ms) but, surprisingly, its direction was value-driven. This suggests covert evaluation of stimulus values prior to first saccade. This was particularly evident for overtrained stimuli [4/8]

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  15. 21. lis 2019.

    Subjects made binary choices between reward predictive stimuli which were well-learned (overtrained), recently learned (novel), or a combination of both (mixed). They were free to saccade around the options and make a choice at any time with a joystick [3/8]

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  16. 21. lis 2019.

    Previous work has shown that where we direct our gaze can have a big impact on what we choose. However, where we choose to gaze during the decision process is not well-characterised, despite the important role it plays [2/8]

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  17. proslijedio/la je Tweet
    17. ruj 2019.

    My first preprint is out, on the modulation of spinal excitability while macaques observe and withhold grasping actions.

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  18. proslijedio/la je Tweet
    26. lip 2019.
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  19. proslijedio/la je Tweet
    21. lip 2019.

    Jon Driver talk by - longer timescale neurons more involved in longer term cognitive processes such as value encoding and decision making.

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  20. proslijedio/la je Tweet
    21. lip 2019.

    Final talk of the morning from student on ‘The role of neuronal timescales in cognition’

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