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2) is a somewhat under-the-radar project working on a full cross-chain protocol. Getting really great cross-chain support is one of the key targets of DeFi right now: there are lots of chains and if we can't use them in the same place the space will be fractured.
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3) Thorchain combines cross-chain validation with a series of staking nodes to allow cross-chain swaps to happen. It's one of the most promising cross-chain projects, and we were really impressed when talking with their team!
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4) FTX supports spot and futures for RUNE; and we're working on adding support for staking as well.
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