Ruchi Malik

@Ruchimk

neuroscientist studying microcircuits in prefrontal cortex and hippocampus | alum

California, USA
Vrijeme pridruživanja: veljača 2014.

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  1. Prikvačeni tweet
    12. srp 2019.

    Excited to share the preprint of my postdoc work w/ in collab w/ Daniel Vogt & John Rubenstein We show that deletion of Tsc1, a gene associated with autism, causes somatostatin interneurons to express parvalbumin & adopt fast-spiking properties

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  2. 31. sij
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  3. proslijedio/la je Tweet
    29. sij

    New work online! Transplanting interneuron stem cells rescues social behavior in PTEN mutant mice, but does so without fixing their abnormal inhibitory circuits. Led by Derek Southwell + s/o to and !

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  4. proslijedio/la je Tweet
    22. sij

    Do you want to figure out how both active and passive head movements impact your primary visual cortex activity. Check out my first postdoc paper:

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    2. sij

    Brains are amazing. Our lab demonstrates that single human layer 2/3 neurons can compute the XOR operation. Never seen before in any neuron in any other species. Out now in . Congrats Albert, Tim  & CO

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    6. pro 2019.
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    Being too self-centred can give rise to anxiety and depression. An effective antidote is to cultivate a sense of altruism, taking the whole of humanity into account. Appreciating the oneness of humanity leads us to recognise our essential equality as human beings.

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  8. proslijedio/la je Tweet
    9. stu 2019.

    Before I heard of optogenetics, I was a mathematician simulating learning and oscillations in neural networks. Now my lab has a bunch of experimental data that demand new models. If you’re looking for postdoc opportunities modeling cortical dynamics please contact me!

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  9. proslijedio/la je Tweet
    7. stu 2019.

    I wrote this up and posted. In some sense it is trivial, yet it is important. If you are using fluorescent reporters (GCAMP, dLight,....) and relating to behavioral events or neural activity, please read it and comment

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  10. proslijedio/la je Tweet
    1. stu 2019.

    Tsc1 represses parvalbumin expression and fast-spiking properties in somatostatin lineage cortical interneurons Tsc1 paper is officially published!!

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  11. proslijedio/la je Tweet
    1. stu 2019.

    New work published: collaboration with and Rubenstein lab, led by , showing that autism gene Tsc1 dynamically regulates PV expression and fast-spiking in SST interneurons well into adulthood!

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  12. proslijedio/la je Tweet
    30. lis 2019.

    New paper from the lab in Neuron along-with a press release from ! Awake hippocampal-prefrontal replay for both spatial learning and memory-guided decision making. Reverse replay for learning from the past, and forward replay for planning future decisions.

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  13. proslijedio/la je Tweet
    17. lis 2019.

    We knew that too much neural excitation is bad for circuit dynamics. Now a surprising link between neural excitation and longevity! Calm down, sleep well, and you'll live longer? Really cool stuff. Regulation of lifespan by neural excitation and REST

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  14. proslijedio/la je Tweet
    26. ruj 2019.

    3 years ago we asked what gamma oscillations do. In this new preprint, shows that cross-hemispheric gamma synchrony is crucial for behavioral reappraisal:

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  15. proslijedio/la je Tweet
    18. srp 2019.

    1/ New in w/ lab: : new opsin + multi-photon holography to image ~4000 cells in 3D volumes over 5 cortical layers while also stimulating ~50 neurons to directly drive visual percepts; data analysis and theory reveal…

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  16. proslijedio/la je Tweet
    15. srp 2019.

    A sensor for inhibitory transmission in the brain from our colleagues

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  17. proslijedio/la je Tweet
    16. srp 2019.

    We are looking for Postdocs and Research Technicians to join us! Please spread the word to any bright, young scientists looking for an exciting postdoctoral research experience, and any motivated recent graduates looking for tech positions.

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  18. proslijedio/la je Tweet
    12. srp 2019.

    Here is a link to a review/model of interneuron specification with Adam Kepecs for ARN. We describe an attractor model which we coin configurational code (as compared to combinatorial) , note similarity to Hopfield networks. Any and all feedback welcome.

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  19. proslijedio/la je Tweet
    11. srp 2019.

    New preprint out (collab w/ Dan Vogt & John Rubenstein): deficiency of the autism-associated gene Tsc1 causes somatostatin+ interneurons to express parvalbumin and fast-spiking properties. This change in phenotype remains reversible even into adulthood:

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  20. proslijedio/la je Tweet
    27. lip 2019.

    (1/n) Latest pre-print from lab! Octopi; open configurable high-throughput imaging platform. Led by an incredible graduate student - we crack puzzle of automated low-cost malaria diagnosis. Remember, malaria still kills ~1/2million people/year

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