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Prikvačeni tweet
My article on
#2019nCoV outbreak is now online: "Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China". Raced to write and revise in one week! Embracing#openinnovation to solve#WuhanCoronavirus crisis. https://f1000research.com/articles/9-72Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Proud to share that I'm working w/ two Chinese biotech companies to produce ACE2-Fc & advance it toward testing in
#2019nCoV infected patients. The#WuhanCoronavirus must be stopped. If any US-based investors, foundations, or companies want to join the effort, please reach out.Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Robert Kruse, MD, PhD proslijedio/la je Tweet
A race against time – we need therapies that can be rapidly tested to treat
#2019nCoV patients, while#Vaccine efforts continue.@RobertLKruse@HopkinsMedicine explains the potential of using ACE2-Fc biologic agent (opinion article awaiting#PeerReview) https://f1000research.com/articles/9-72 pic.twitter.com/mRjzq8gnWx
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Thinking about
$REGN announcement to investigate neutralizing antibodies (NAbs) against#2019nCoV, still a significant lead time to get a candidate. Moreover, almost all papers only use NAbs to prevent infection in SARS#coronavirus models, our best surrogate to the current virusHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Robert Kruse, MD, PhD proslijedio/la je Tweet
Aiding global health efforts against
#2019nCoV -@RobertLKruse@HopkinsMedicine recommends pursuing ACE2-Fc biologic agent. He explains the potential benefits of using this agent, providing that manufacturing soon starts on an available sequence#Outbreak https://f1000research.com/articles/9-72 pic.twitter.com/allKqbRpAN
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Robert Kruse, MD, PhD proslijedio/la je Tweet
Wuhan Coronavirus Looks Increasingly Like a Pandemic, Experts Say - via
@nytimeshttps://www.nytimes.com/2020/02/02/health/coronavirus-pandemic-china.html …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
I wonder if
@Genscript could sell these#2019nCoV plasmids for just a little less? If they want people to work on vaccines, therapies, and diagnostics around the world for this crisis, maybe saving researchers money or giving away for free rather than $420 https://www.molecularcloud.org/How-to-detect-the-2019-novel-coronavirus.html?src=topbanner …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
A soluble, receptor decoy fused to an Fc domain (ACE2-Fc) should create a neutralizing antibody against
#2019nCoV#coronavirus that could treat & protect patients from infection. Virus couldn't mutate to escape therapy. Read more here: https://f1000research.com/articles/9-72/v1 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
For now, seemingly a surrogate virus with Vesicular Stomatitis Virus (VSV) pseudotyped with
#2019nCoV Spike protein could be utilized by many labs, similar to what they did in this study just published. https://www.biorxiv.org/content/10.1101/2020.01.31.929042v1.full.pdf …Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Has there been any discussion on how labs should be testing new therapies against
#2019nCoV? If in vitro data is required, few labs are BSL-3 certified. If surrogate pseudotyped viruses are used, can we rely on that data? Mice shouldn't be naturally infectious, either.Prikaži ovu nitHvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Special thanks to the
@F1000Research team for working with me to expedite publishing this past week to reach the#2019nCoV#coronavirus research community quickly, important in this outbreak scenario. https://f1000research.com/articles/9-72/v1 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Always amazing how the little details in CAR molecule design have such a big difference, here hinge and TM domain choice, and likely Ab has different affinity. Saw the same in my HBV CAR-T work on hinge length.https://twitter.com/NCIDirector/status/1220044651706478593 …
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Proud to share my first publication while at
@HopkinsMedicine and first in my field of transfusion medicine. We evaluated a platform by@Immucor to perform automated ABO antibody titers in the blood bank. Applications in transplant medicine & more! https://www.ncbi.nlm.nih.gov/pubmed/31957889Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi -
Not shocking that a linear ssDNA fragment might find its way to integrate into the genome, especially at high doses...https://twitter.com/cells_nnm/status/1214224635916685313 …
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Reminds me of my recent reviewer, who offered these gems: "unfortunately the paper is not well written", "lack in fundamental understanding", & "authors should familiarize themselves with the literature." Manuscript was accepted with minor edits.https://www.sciencemag.org/news/2019/12/rude-paper-reviews-are-pervasive-and-sometimes-harmful-study-finds?utm_source=Nature+Briefing&utm_campaign=10b26858f6-briefing-wk-20191213&utm_medium=email&utm_term=0_c9dfd39373-10b26858f6-42830439 …
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Cool paper. Could really improve ability to purify cell populations of interest in manufacturing of cell therapies. Example: Could capture CD3 T cells with aptamer, then add oligo antidote to seamlessly release. Very useful for the cell therapy field.https://www.cell.com/cell-chemical-biology/fulltext/S2451-9456(19)30400-3#%20 …
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Robert Kruse, MD, PhD proslijedio/la je Tweet
Interested in
#celltherapies? Here's a new collection of freely accessible reviews https://go.nature.com/2qWhbdx - covering regulatory T cells for immune disorders, gamma delta T cells for cancer and engineered haematopoietic stem cells for blood disorderspic.twitter.com/povbGySCLZ
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The eternal debate in transfusion medicine continues...https://twitter.com/KinjalShah_MD/status/1204460653685153793 …
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To me, this is a major issue. Hard to see the FDA liking this, unless the risk-benefit ratio is there for these patients. But other methods can knockdown PD1 in T cells w/o risk.
#CRISPRhttps://twitter.com/OrentasR/status/1203298174930169856 …Hvala. Twitter će to iskoristiti za poboljšanje vaše vremenske crte. PoništiPoništi
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