Block paint bucket: you block someone /and/ all of their followers (transitively) until you have blocked All Of Twitter.
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Or an intelligent fill tool that blocks some reasonable neighborhood of the target.
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Relationship to continue flood fill could be something like "B follows A and frequently likes A's tweets".
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Magic lasso to round up all the twerps you don't like?
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Select all that are visually indistinguishable.
End of conversation
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