here's someone who can hear different lossless compression levels in flac http://www.audiostream.com/content/dbpoweramps-flac-lossless-uncompressed-wish-come-true#901sPcF7FIE5AcyT.97 …pic.twitter.com/z2DSW9lkMQ
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Generally it's the cpu going in/out of sleep states that seems to produce the most noticeable noise, so you'd want a 100%-cpu-load codec. ;)