Or maybe stop funding the failed drug war that made these cartels so powerful 
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Even if that's the case it wouldn't completely solve the issues, there are still the Latin American market, Europe has a massive market for drugs, and well some parts of Asia (Philippines for example), Australia, and some parts of the middle east. They could also just jump to...
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... "the next thing" be wash money, mafia style cartels, dumping nuclear waste or trash in other countries, and so on. I'll try to source this later but my memory is shit (and you can probably find better sources than me lol)
End of conversation
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