Relative affinities for Rhinolophus sinica ACE-2 and human ACE-2 for four chimeric viruses encoding different spike receptor binding domains in an otherwise-constant bat SARSr-CoV genomic context (chimeras constructed in https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006698 …). https://www.biorxiv.org/content/10.1101/2020.05.13.093658v1.full.pdf …
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WIV constructed a series of novel chimeric viruses encoding different receptor binding domains--with different receptor binding affinities--in an otherwise constant genomic context. And did so using "seamless ligation" procedures that leave no signatures of human manipulation.
"All work with the infectious virus was performed under biosafety level 2 conditions"
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Can someone please point me towards the info that it was done under BL2 conditions i could not see it in the papers
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The quote is taken directly from the preprint. Try CTRL-F.
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