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Here is all the information on the blood libel against ivermectin and how it is a miracle drug for HUMANS. https://www.theblaze.com/op-ed/horowitz-fda-disseminates-dangerous-and-libelous-misinformation-against-lifesaving-covid-treatment … As for how a drug originally used for river blindness helps against covid, the following is from Dr. Ryan Cole.
Mechanisms of action of #ivermectin against SARS-CoV-2:
1. Inhibits binding at ACE2 an TMPRSS2 keeping the virus from entering our cells
2. Blocks alpha/beta importin (the virus cell taxi) keeping it from gettin to the nucleus
3. Blocks the viral replicase zipper (RdRp)
4. 3-Chimotrypsin protease inhibition (keeps the virus from assembling) 5. Ivermectin strengthens our natural antiviral cell activity by increasing our natural interferon production (this Counters SARSCOV2 activity which inhibits cellular interferon)
6. Decreases IL-6 and other inflammatory cytokines through NF Kappa Beta downregulation, taking the patient from a cytokine storm to calm. 7. Binds NSP14 necessary for viral replication and blocks it (equals less virus).
8. Most important mechanism is inhibiting binding to CD147 receptor on red cells, platelets, lung and blood cell lining. Ivermectin keeps the virus from binding here and decreases deadly clotting.
Now for more detail on each of the mechanisms, per Dr. Cole:
1) "Ivermectin hinders binding of SARS-COV2 spike protein at the ACE2 receptor . Ivermectin binds not only to the virus spike, but also to the ACE2 receptor (yes, more strongly than remdesivir).
.."This is the primary receptor on our cell surface where the virus binds and then gets gulped into the cell. If the virus can’t bind, it can’t get in. If it can’t get in, it can’t replicate. Both the key and the lock are altered and don’t work together in the presence of IVM."
"We have heard much about ACE2 but TMPRSS2 is a serine protease that is needed on the cell surface to prime the Spike protein. Ivermectin inhibits this." https://pubmed.ncbi.nlm.nih.gov/32871846/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/ … https://www.frontiersin.org/articles/10.3389/fmicb.2020.592908/full … https://www.cell.com/cell/pdf/S0092-8674(20)30229-4.pdf …
2) "It binds to the alpha/beta importing and saturates it. This is the “taxi/uber” the virus uses to ride into the cell to arrive at the area where it would replicate."
"So ivermectin essentials takes up that “taxi/uber” seats so the virus has trouble getting a ride in to where it needs to be to copy itself. https://pubmed.ncbi.nlm.nih.gov/22417684/ Alpha/Beta importin ivermectin mechanism information we have known for almost a decade"
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