Its not the specfic indirect measurements that are a problem, its linking multiple indirect measures with incomplete information. gene=>brain structure =>cog func =>IQ => success - each connection is problematic, overall, really dangerous.
And do you agree with her 4th pt? Or do you agree that it’s bizarre gibberish to claim that only something that tests for the presence of whatever X is defined as can be an indicator of X?
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I agree with her. Though I think you are not exactly accurate in characterizing her statement. she is pointing out that operational characteristics like IQ are not related to only biology, and so any statistical relationships cannot be used for effective screening
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Okay if you agree with her there is nothing to discuss; she doesn’t understand how indicators work.
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she doesn't have to, the issue is the quality of the data - GIGO
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/sigh. Measurement error reduces the efficiency of GWAS and puts a ceiling on PGS variance, but it doesn't make GWAS impossible, and you can still get plenty of results even with crummy IQ measurements like UKBB.
End of conversation
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for instance, IQ may correlate with genes for asian facial characteristics or schizophrenia
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It doesn't because you're making bullshit up again. The IQ GWASes are done in homogenous Europeans, non-Europeans are thrown out, PCs are added, and the PGSes repeatedly validated within-family. And the genetic correlation with schizophrenia is negative, not positive.
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homogeneous europeans ? LOL
End of conversation
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