I had totally forgotten about the homemade intranasal vaccine plot line (tl;dr it’s easy to do but nobody has yet publicly revealed serology results after doing it)
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the George Church ones I’d heard of seemed pretty legit to me tbh, but I’m also the sort of person who last summer was like “if we don’t hang a vaccine approved by EOY, I’m switching to making genetically modified tomato vaccines in my backyard and nobody can stop me”
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as for this writeup’s vaccine, it hadn’t occurred to me that you could just *buy* the peptides straight... and then take them intranasally. all my immune models do say “yeah this should be fine,” so I’ll be interested to see how the commercial test results work out!
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I would want to be super cautious about the development process (thinking carefully about the peptide design) because antibody-dependent enhancement is a confusing blindspot for me, but it looks like the biologists behind radvac have taken care of the careful design part
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though I am kind of confused why these are really small peptides and not the full spike protein with a stabilizing loop, like I’ve seen done in other vaccines
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Update: I defer to on this one!
The peptides appear only supported by in silico simulations 😑
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I looked into this, because yay citizen science.
I could not find one research study using any of the peptides in the RADVAC white paper that found they inhibited SARS-CoV-2 infection in cells, let alone animals or humans. twitter.com/Conaw/status/1…
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