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Nothing so complicated is needed. Hermode tuning already works pretty well, and is supported by various DAWs and VSTs.
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It's surprising that old fashioned temperaments haven't become more in vogue in popular music, as many songs are in one key, and 2020-era keyboards often have alternative temperaments. This would give pop bands purer fifths and sweeter thirds.
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This isn't really built into the nature of reality, just the nature of musical notation / pianos. For vocals, strings, trombone, synth, you can have music that sounds perfectly harmonious (or disharmonious).
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