Are there any approaches today that get at this: “…a new epistemological theory that explains how brains create explanatory knowledge and hence defines, in principle, without ever running them as programs, which algorithms possess that functionality and which do not.”?
If course. They put the nervous system in all sorts of possible configurations. Some of those have deleterious effects on people’s epistemology, but if one can avoid that, the experiment can contribute important insights. Such as integration of the self being a separate process.
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.."the experiment can contribute important insights"... absolutely. I am happy to report I (finally) tripped on shrooms on my 33th birthday on Texel. :)
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It is not strictly necessary to do it yourself, of course, bit to take it seriously. Erowid is an incredible resource of case studies, and there is also a lot of literature.
End of conversation
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