In most cases, depression and anxiety are your mind's reflection of life circumstances you cannot or did not adapt to. But to act on changing this, and for recovery of your reward circuits, medication may be crucially important.https://twitter.com/amelapay/status/950559416394354688 …
Sometimes depression is endogenous, i.e. not caused by the environment or the individual's trajectory though it. Also, almost all successful treatment of non-endogenous conditions will have to address self-modeling defects.
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According to the most current science there is always a physical reason for depression, as it's one of the possible responses to an environment that fails to meet the body's biological needs. Fight/flight/freeze/flow are the four basic types of response. Depression is freeze.
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Of course there is always a physical reason if you don't live in a dualist universe. The question is whether the reason is in the brain's environment, or in the way the brain models its interaction with the environment, or in deficits of the brain's regulation capabilities.
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