Acetaminophen in opioids is oddly reminiscent of Prohibition spiking of alcohols, which killed tons of people.
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I wouldn't know
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Someone needs to do that; it is possibly the only way to win the argument, and it seems to be important.
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The cocktail napkin (US) math: Acetaminophen-associated liver failure kills <500/year of which 30-40% related to prescription opioids...
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Versus 20k deaths/year from prescription drug overdose + 13k/year from heroin OD. So you need deterrence rate of ~0.6% to "justify", but...
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