There are tons of rodent studies showing that various compounds have “neuroprotective” effects: that is, if you damage the brain by hypoxia or blunt force trauma, the animal’s cognitive function recovers better if you administer a drug right after injury.
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These studies basically never translate to humans. Casually it seems like an unusually bad translation rate, compared to drugs in general. Anyone know why?
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Replying to @s_r_constantin
I have no expertise here, but the mouse genome induces senescence within a couple years, while the same neurons have to last for many decades in humans. Mice should have much more leeway in increasing recovery and longevity, and easier routes to activate them.
12:09 PM - 4 Oct 2019
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