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Plinz's profile
Joscha Bach
Joscha Bach
Joscha Bach
@Plinz

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Joscha Bach

@Plinz

FOLLOWS YOU. Artificial Intelligence, Cognitive Architectures, Computation. The goal is integrity, not conformity.

San Francisco, CA
bach.ai
Joined April 2009

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    1. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      At around 3 weeks, the symmetry is broken as the heart twists. It then develops into a highly asymmetric organ.pic.twitter.com/5QtixM9NDk

      1 reply 2 retweets 24 likes
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    2. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      A problem with cilia might explain diseases like Kartagener's, which is a ciliary dysmotility disorder characterised by multiple respiratory issues along with dextrocardia (heart on the wrong side)

      3 replies 0 retweets 18 likes
      Show this thread
    3. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      The asymmetry is thought to come from *molecular* chirality of some component in the cilia. So we might owe our entire anatomy to the shape of an individual molecule.

      1 reply 2 retweets 32 likes
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    4. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      However - mammals like pigs don't have those cilia and are still laid out in a similar manner to us, so some propose that all cells have a natural chirality. Again, this is thought to be due to the chiral nature of our most fundamental molecules - proteins, sugars & DNA.pic.twitter.com/52D6sz2DBr

      2 replies 0 retweets 18 likes
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    5. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      BTW, the chirality of organic molecules was first noticed due to a curious property of light - linear plane-polarised light beams behave in a chiral manner, with L and R 'handed' components. Chiral molecules in the beam act differently with each part (snuck some physics in).

      3 replies 0 retweets 27 likes
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    6. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      Personally I find the idea that we owe our macroscopic layout - where each organ goes - to the asymmetry present at the microscopic level, which has set off a chain reaction of asymmetry for millions of years of evolution, pretty bloody amazing.

      1 reply 9 retweets 55 likes
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    7. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      So next time some beauty magazine raves about symmetry being more attractive, remember that in a symmetrical world, we'd all be dead. Then give them two chiral fingers.pic.twitter.com/VVG6KKDSkK

      4 replies 11 retweets 88 likes
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    8. Medlife Crisis (Rohin)‏Verified account @MedCrisis 4 Jul 2018
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      Medlife Crisis (Rohin) Retweeted Medlife Crisis (Rohin)

      BONUS ADDITIONAL TWEETS TO MAKE IT MORE ASYMMETRICAL: Thanks to @Plinz for asking a great question, I have added a few more tweets for a bit more depth 👍🏽 https://twitter.com/MedCrisis/status/1014412974063316993 …

      Medlife Crisis (Rohin) added,

      Medlife Crisis (Rohin)Verified account @MedCrisis
      Good points. As I said, cilia is the leading theory. Mice & humans use cilia but some animals don't. When I talked about intrinsic asymmetry in cells, I meant the initiation must be earlier than the cilia phase. Some say asymmetries exist ~first cell cleavage after fertilisation. https://twitter.com/Plinz/status/1014382798805913600 …
      Show this thread
      3 replies 0 retweets 3 likes
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    9. Chris Charlton‏ @ctcharlton 5 Jul 2018
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      Replying to @MedCrisis @Plinz

      Chris McManus wrote about this in _Right Hand, Left Hand_ - it even won a prize https://www.amazon.co.uk/dp/0753813556/ref=cm_sw_r_cp_apa_i_TFFpBbYFGDSN5 …

      1 reply 0 retweets 1 like
    10. Medlife Crisis (Rohin)‏Verified account @MedCrisis 5 Jul 2018
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      Replying to @ctcharlton @Plinz

      Medlife Crisis (Rohin) Retweeted Medlife Crisis (Rohin)

      Thanks! @nick_grundy alerted me to this book a couple of days ago, looking forward to ithttps://twitter.com/MedCrisis/status/1014276034378784768 …

      Medlife Crisis (Rohin) added,

      Medlife Crisis (Rohin)Verified account @MedCrisis
      Replying to @nick_grundy
      Thank you, I did not know that book. Have bought a copy - the questions posed in the blurb are things I've often wondered!
      1 reply 0 retweets 0 likes
      Joscha Bach‏ @Plinz 5 Jul 2018
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      Replying to @MedCrisis @ctcharlton @nick_grundy

      Could you explain how lateral asymmetry is fundamentally different from other asymmetry directions in the body?

      5:36 AM - 5 Jul 2018
      1 reply 0 retweets 0 likes
        1. Medlife Crisis (Rohin)‏Verified account @MedCrisis 5 Jul 2018
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          Replying to @Plinz @ctcharlton @nick_grundy

          Not sure that I can, not really my field I'm afraid - I would guess something to do with our field of vision being naturally landscape-oriented. Might be an answer in the book...will let you know if I find it

          0 replies 0 retweets 0 likes
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