The heart's origins as a midline tube & sensitivity to errors in asymmetry explain why there is a whole field dedicated to congenital heart disease but no other organs. #ACHDpic.twitter.com/r1NAxutkqZ
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The heart's origins as a midline tube & sensitivity to errors in asymmetry explain why there is a whole field dedicated to congenital heart disease but no other organs. #ACHDpic.twitter.com/r1NAxutkqZ
At around 3 weeks, the symmetry is broken as the heart twists. It then develops into a highly asymmetric organ.pic.twitter.com/5QtixM9NDk
A problem with cilia might explain diseases like Kartagener's, which is a ciliary dysmotility disorder characterised by multiple respiratory issues along with dextrocardia (heart on the wrong side)
The asymmetry is thought to come from *molecular* chirality of some component in the cilia. So we might owe our entire anatomy to the shape of an individual molecule.
However - mammals like pigs don't have those cilia and are still laid out in a similar manner to us, so some propose that all cells have a natural chirality. Again, this is thought to be due to the chiral nature of our most fundamental molecules - proteins, sugars & DNA.pic.twitter.com/52D6sz2DBr
BTW, the chirality of organic molecules was first noticed due to a curious property of light - linear plane-polarised light beams behave in a chiral manner, with L and R 'handed' components. Chiral molecules in the beam act differently with each part (snuck some physics in).
Personally I find the idea that we owe our macroscopic layout - where each organ goes - to the asymmetry present at the microscopic level, which has set off a chain reaction of asymmetry for millions of years of evolution, pretty bloody amazing.
So next time some beauty magazine raves about symmetry being more attractive, remember that in a symmetrical world, we'd all be dead. Then give them two chiral fingers.pic.twitter.com/VVG6KKDSkK
Medlife Crisis (Rohin) Retweeted Medlife Crisis (Rohin)
BONUS ADDITIONAL TWEETS TO MAKE IT MORE ASYMMETRICAL: Thanks to @Plinz for asking a great question, I have added a few more tweets for a bit more depth
https://twitter.com/MedCrisis/status/1014412974063316993 …
Medlife Crisis (Rohin) added,
Indeed; it made me think for the first time about symmetry breaking in generative automata :)
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