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Plinz's profile
Joscha Bach
Joscha Bach
Joscha Bach
@Plinz

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Joscha Bach

@Plinz

FOLLOWS YOU. Artificial Intelligence, Cognitive Architectures, Computation. The goal is integrity, not conformity.

San Francisco, CA
bach.ai
Joined April 2009

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    1. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      One interesting and poorly understood phenomenon is the relationship with sex determination: in human hermaphrodites, ovaries develop on the left, testes on the right.

      1 reply 1 retweet 21 likes
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    2. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      The heart's origins as a midline tube & sensitivity to errors in asymmetry explain why there is a whole field dedicated to congenital heart disease but no other organs. #ACHDpic.twitter.com/r1NAxutkqZ

      1 reply 11 retweets 45 likes
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    3. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      At around 3 weeks, the symmetry is broken as the heart twists. It then develops into a highly asymmetric organ.pic.twitter.com/5QtixM9NDk

      1 reply 2 retweets 24 likes
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    4. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      A problem with cilia might explain diseases like Kartagener's, which is a ciliary dysmotility disorder characterised by multiple respiratory issues along with dextrocardia (heart on the wrong side)

      3 replies 0 retweets 18 likes
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    5. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      The asymmetry is thought to come from *molecular* chirality of some component in the cilia. So we might owe our entire anatomy to the shape of an individual molecule.

      1 reply 2 retweets 32 likes
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    6. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      However - mammals like pigs don't have those cilia and are still laid out in a similar manner to us, so some propose that all cells have a natural chirality. Again, this is thought to be due to the chiral nature of our most fundamental molecules - proteins, sugars & DNA.pic.twitter.com/52D6sz2DBr

      2 replies 0 retweets 18 likes
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    7. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      BTW, the chirality of organic molecules was first noticed due to a curious property of light - linear plane-polarised light beams behave in a chiral manner, with L and R 'handed' components. Chiral molecules in the beam act differently with each part (snuck some physics in).

      3 replies 0 retweets 27 likes
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    8. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      Personally I find the idea that we owe our macroscopic layout - where each organ goes - to the asymmetry present at the microscopic level, which has set off a chain reaction of asymmetry for millions of years of evolution, pretty bloody amazing.

      1 reply 9 retweets 55 likes
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    9. Medlife Crisis (Rohin)‏Verified account @MedCrisis 2 Jul 2018
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      So next time some beauty magazine raves about symmetry being more attractive, remember that in a symmetrical world, we'd all be dead. Then give them two chiral fingers.pic.twitter.com/VVG6KKDSkK

      4 replies 11 retweets 88 likes
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    10. Medlife Crisis (Rohin)‏Verified account @MedCrisis 4 Jul 2018
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      Medlife Crisis (Rohin) Retweeted Medlife Crisis (Rohin)

      BONUS ADDITIONAL TWEETS TO MAKE IT MORE ASYMMETRICAL: Thanks to @Plinz for asking a great question, I have added a few more tweets for a bit more depth 👍🏽 https://twitter.com/MedCrisis/status/1014412974063316993 …

      Medlife Crisis (Rohin) added,

      Medlife Crisis (Rohin)Verified account @MedCrisis
      Good points. As I said, cilia is the leading theory. Mice & humans use cilia but some animals don't. When I talked about intrinsic asymmetry in cells, I meant the initiation must be earlier than the cilia phase. Some say asymmetries exist ~first cell cleavage after fertilisation. https://twitter.com/Plinz/status/1014382798805913600 …
      Show this thread
      3 replies 0 retweets 3 likes
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      Joscha Bach‏ @Plinz 4 Jul 2018
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      Replying to @MedCrisis

      Our body is a cellular automaton on a selfgenerated lattice. There are several obvious ways to break the symmetry, but using the chirality of molecules within the cells seems hard, because you'd have to align these molecules in space *across* cells first.

      1:21 AM - 4 Jul 2018
      0 replies 0 retweets 0 likes

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