Certainly not. But in this case, it gives a difference in degree rather than a difference in kind. I was reacting to some ridiculousness in that banana thread
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Replying to @Pinboard
True, but no one would have a problem if you said "Methamphetamines and amphetamines are both strong simulants."
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Replying to @KardOnIce
They’re more than that. They have very similar effects, same mechanism of action, create cross-tolerance. I think the analogy to heroin/fentanyl is a good one
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Replying to @Pinboard
Which is all true, but it's not inherently because it's methylated is what I'm trying to get at. Fentanyl and heroin aren't very similar structurally, but do target (similar? the same? not my speciality) receptors.
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Replying to @KardOnIce
I think a problem is we're speaking in different contexts. Chemically, you are completely right. Methylating an organic molecule can have effects on its biological activity out of all proportion to the 'smallness' of the change.
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Replying to @Pinboard
But that's mainly what I'm trying to highlight (even in context). Fentanyl and heroin both stimulate the same receptor (μ receptors), despite very different structures (PubChem 3D conformer images below, not aligned to the active site).pic.twitter.com/4UoqizcmIb
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Replying to @KardOnIce
I've honestly lost the thread of the argument. What is it you'd like me to concede?
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Replying to @Pinboard
It's the "methylated duck still quacks like a duck".
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Replying to @Pinboard
If you can get me a meeting with IACUC, sure ;) Maybe a fruit fly (I have stories of friends centrifuging them live without any consequence).
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Three drops of this on a saltine, and a discreet visit to the local park, should do it.http://blogs.sciencemag.org/pipeline/archives/2006/05/23/cant_buy_these_thrills …
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