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Pinboard

@Pinboard

The light inside is broken, but I still work. The Cadillac of online bookmarking sites. Alleged nocoiner. http://pinboard.in  maciej@ceglowski.com +1 415 610 0231

Lonely street of broken dreams
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Joined July 2009

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    1. Pinboard‏ @Pinboard 22 Apr 2018
      Replying to @KardOnIce

      Certainly not. But in this case, it gives a difference in degree rather than a difference in kind. I was reacting to some ridiculousness in that banana thread

      1 reply 0 retweets 0 likes
    2.  👻 🎃 Status Quo  🎃 👻‏ @KardOnIce 22 Apr 2018
      Replying to @Pinboard

      True, but no one would have a problem if you said "Methamphetamines and amphetamines are both strong simulants."

      2 replies 0 retweets 0 likes
    3. Pinboard‏ @Pinboard 22 Apr 2018
      Replying to @KardOnIce

      They’re more than that. They have very similar effects, same mechanism of action, create cross-tolerance. I think the analogy to heroin/fentanyl is a good one

      1 reply 0 retweets 0 likes
    4.  👻 🎃 Status Quo  🎃 👻‏ @KardOnIce 22 Apr 2018
      Replying to @Pinboard

      Which is all true, but it's not inherently because it's methylated is what I'm trying to get at. Fentanyl and heroin aren't very similar structurally, but do target (similar? the same? not my speciality) receptors.

      1 reply 0 retweets 0 likes
    5. Pinboard‏ @Pinboard 22 Apr 2018
      Replying to @KardOnIce

      I think a problem is we're speaking in different contexts. Chemically, you are completely right. Methylating an organic molecule can have effects on its biological activity out of all proportion to the 'smallness' of the change.

      1 reply 0 retweets 0 likes
    6.  👻 🎃 Status Quo  🎃 👻‏ @KardOnIce 22 Apr 2018
      Replying to @Pinboard

      But that's mainly what I'm trying to highlight (even in context). Fentanyl and heroin both stimulate the same receptor (μ receptors), despite very different structures (PubChem 3D conformer images below, not aligned to the active site).pic.twitter.com/4UoqizcmIb

      2 replies 0 retweets 0 likes
    7. Pinboard‏ @Pinboard 22 Apr 2018
      Replying to @KardOnIce

      I've honestly lost the thread of the argument. What is it you'd like me to concede?

      1 reply 0 retweets 0 likes
    8.  👻 🎃 Status Quo  🎃 👻‏ @KardOnIce 22 Apr 2018
      Replying to @Pinboard

      It's the "methylated duck still quacks like a duck".

      1 reply 0 retweets 0 likes
    9. Pinboard‏ @Pinboard 22 Apr 2018
      Replying to @KardOnIce

      Go methylate a duck and tell me if it quacks!

      1 reply 0 retweets 0 likes
    10.  👻 🎃 Status Quo  🎃 👻‏ @KardOnIce 22 Apr 2018
      Replying to @Pinboard

      If you can get me a meeting with IACUC, sure ;) Maybe a fruit fly (I have stories of friends centrifuging them live without any consequence).

      1 reply 0 retweets 0 likes
      Pinboard‏ @Pinboard 22 Apr 2018
      Replying to @KardOnIce

      Three drops of this on a saltine, and a discreet visit to the local park, should do it.http://blogs.sciencemag.org/pipeline/archives/2006/05/23/cant_buy_these_thrills …

      10:43 AM - 22 Apr 2018
      0 replies 0 retweets 0 likes

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