Zing! Except adderall is literally amphetamine. A methylated duck still quacks. The salient difference between adderall and meth is that the government doesn't manufacture high-purity meth for the lower classeshttps://twitter.com/thalestral/status/987435439614144512 …
I think a problem is we're speaking in different contexts. Chemically, you are completely right. Methylating an organic molecule can have effects on its biological activity out of all proportion to the 'smallness' of the change.
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But that's mainly what I'm trying to highlight (even in context). Fentanyl and heroin both stimulate the same receptor (μ receptors), despite very different structures (PubChem 3D conformer images below, not aligned to the active site).pic.twitter.com/4UoqizcmIb
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A methylated compound doesn't necessarily quack like a duck, but in this case it does: the important part is the physiological response.
End of conversation
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