Zing! Except adderall is literally amphetamine. A methylated duck still quacks. The salient difference between adderall and meth is that the government doesn't manufacture high-purity meth for the lower classeshttps://twitter.com/thalestral/status/987435439614144512 …
They’re more than that. They have very similar effects, same mechanism of action, create cross-tolerance. I think the analogy to heroin/fentanyl is a good one
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Which is all true, but it's not inherently because it's methylated is what I'm trying to get at. Fentanyl and heroin aren't very similar structurally, but do target (similar? the same? not my speciality) receptors.
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I think a problem is we're speaking in different contexts. Chemically, you are completely right. Methylating an organic molecule can have effects on its biological activity out of all proportion to the 'smallness' of the change.
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